Properties and Synthetic Utility of N-Substituted Benzotriazoles.

The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

Recent developments in sulfone chemistry

The four-component condensation of amines and carbonyl compounds with isocyanides11 and suitable acid components (water, thiosulfuric acid, hydrogen selenide, hydrogen azide, cyanic acid, thiocyanic acid, carboxylic acids, methyl hydrogen carbonate) to form α-amino acid derivatives was discovered in 1959. This reaction principle shares some features with the Strecker synthesis and the Passerini reaction. The four-component condensation affords easy and effective one-pot synthesis of complex molecules from simple building blocks. Only in recent years, however, have the preparative advantages of the four-component condensation been exploited by numerous authors in the synthesis of diverse natural products and related compounds, although many of the possibilities opened by this principle were recognized more than two decades ago. In this progress report some instructive syntheses of various antibiotics are reviewed. The design of each of these syntheses involves a four-component condensation as key step, by means of which lengthy sequences of reactions are avoided, which otherwise would be required to achieve the synthetic goal.

From Isocyanides via Four-Component Condensations to Antibiotic Syntheses†‡

The term functionalized isocyanides refers to all those isocyanides in which a neighbouring functional group can finely tune the reactivity of the isocyano group or can be exploited in post-functionalization processes. In this manuscript, we have reviewed all the isocyanides in which the pendant functional group causes either deviation from or reinforces the normal reactivity of the isocyano group and categorized them to highlight their common features and differences. An analysis of their synthetic potential and the possible unexplored directions for future research studies is also addressed.

To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis

General one-step synthesis of nitriles from ketones using tosylmethyl isocyanide - introduction of a one-carbon unit

A synthetic method for direct conversion of ketones into cyanides. Introduction of a one carbon unit.

A Simple One-Step Synthesis of 2-Cyanoadamantane, a Precursor to Adamantane-2-Carboxylic Acid

A new synthesis of α-hydroxy aldehydes from ketones and tosylmethylisocyanide

A new synthesis of thiazoles from tosylmethylisocyanide and carboxymethyl dithioates

O. H. Oldenziel

Papers

General one-step synthesis of nitriles from ketones using tosylmethyl isocyanide - introduction of a one-carbon unit

A synthetic method for direct conversion of ketones into cyanides. Introduction of a one carbon unit.

A Simple One-Step Synthesis of 2-Cyanoadamantane, a Precursor to Adamantane-2-Carboxylic Acid

A new synthesis of α-hydroxy aldehydes from ketones and tosylmethylisocyanide

A new synthesis of thiazoles from tosylmethylisocyanide and carboxymethyl dithioates