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Rational Design of Sequestering Agents for Plutonium and Other Actinides

Publisher Summary This chapter describes methods of treating heavy metal intoxication. The chapter discusses the common ground between different approaches to chelation therapy rather than to be over-concerned with the details of individual metal toxicity and its treatment. The chapter also discusses some other medical applications of chelating agents that have become prominent in the past few years. Present treatment of acute iron and lead poisoning is usually gratifyingly successful and a few new agents have been found which appear to have considerable potential. Special attention must be devoted to this interrelationship if metal complexation in areas of medicine other than chelation therapy is to be effectively exploited. The therapeutic potential of chelating agents as a class of compounds is thus, probably, unparalleled. However, all depends on the future design of agents with sufficient chemical and physical selectivity to achieve very specific biochemical objectives.

The present status of chelating agents in medicine.

The solution chemistry of the actinide elements has been explored in aqueous and organic solutions. While the relative stabilities of the actinide oxidation states and the types of complexes formed with the actinide cations in these states vary between solvents, the fundamental principles governing their redox reactions and their complexation strengths are the same regardless of the solvent. This chapter focuses on aqueous actinide chemistry, reflecting the wide variety of studies on actinide reactions in aqueous solutions. However, three factors that are important for actinides in non–aqueous solvents should be noted. First, in non–aqueous solvents, the formation of neutral cation–anion ion pairs is often dominant due to the lower (as compared to water) dielectric constants of the solvents. Second, non–aqueous conditions also allow the formation of complexes between actinide cations and ligands containing soft Lewis base groups, such as sulfur. Third, non–aqueous solvents are often useful for stabilizing redox–sensitive actinide complexes, as oxidation states that are unstable in aqueous solution may be stable in non–aqueous solutions (Mikheev et al., 1977; Hulet et al., 1979).

Actinides in Solution: Complexation and Kinetics

LBL-11533 C Preprint To be published as a Book Chapter in Structure and Bonding Vol. 43, 1980, Springer-Verlag, Heidelberg. West Germany . ACTINIDE-SPECIFIC SEQUESTERING AGENTS AND DECONTAMINATION APPLICATIONS William L. Smith and Kenneth N. Raymond July 1980 TWO-WEEK LOAN COP This is a Library Circulating Copy which may be borrowed for two weeks. Prepared for the U.S. Department of Energy under Contract W-7405-ENG-48

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Actinide-specific sequestering agents and decontamination applications

https://escholarship.org/content/qt3s72p6fx/qt3s72p6fx.pdf?t=p0t1oj

Actinide-specific complexing agents: their structural and solution chemistry

Mixed ligand derivatives of 1:1 Th(IV) - DTPA chelate with some hydroxy acids(I)

Potentiometric studies of the mixed ligand derivatives of 1∶1-Th(IV)—DTPA chelate (whereDTPA=diethylene-triamine pentaacetic acid) with certain secondary ligands, such as lactic, mandelic and o-hydroxynaphthoic acids have been carried out. The pH-titrations of the reaction mixtures containing 1∶1∶1 molar ratio of metal ion toDTPA to secondary ligand have shown the formation of 1∶1∶1 ternary complexes at higher pH (≈8). The equilibrium constants of the resulting mixed complexes have been determined at 30±1°C and μ=0.1 (KNO3) and the order of stability in terms of secondary ligands has been found to be o-hydroxy naphthoic acids>mandelic acid>lactic acid.

O. P. Pachauri

Papers

Mixed ligand derivatives of 1:1 Th(IV) - DTPA chelate with some hydroxy acids(I)

Mischligandenderivate des 1:1-Th(IV)—DTPA-Chelates mit Milchsäure, Mandelsäure und o-Hydroxynaphthoesäuren

Mixed ligand derivatives of 1 - 1-thorium(iv)-dtpa chelate with lactic, mandelic and o-hydroxynaphthoic acids