Layered double hydroxides (LDHs) with two dimensional structure have been attracted considerable interest in exploring new intercalative nanohybrids, such as inorganic-LDHs, organic-LDHs and bio-LDHs ones, which often exhibit extraordinarily synergetic effects and complementary performances. More recently, bio-related nanotechnology becomes one of the most essential research field in the viewpoint of the health and safety of human being. In this regard, LDHs have been focused as an important inorganic material for gene and drug delivery carriers with imaging and targeting functions. In the present review, an attempt has been made to describe gene delivery systems based on LDH nanoparticles in terms of synthetic routes of gene-LDH nanohybrids, their physico-chemical properties, intercellular uptake mechanisms, intracellular trafficking pathways and drug resistance, and passive and active targeting functions in in-vitro and in-vivo, and finally imaging functions. And recent studies of gene-therapies with LDHs are also discussed from the viewpoint of state-of-the-art nanohybrids technology.

2D Nanostructured Metal Hydroxides with Gene Delivery and Theranostic Functions; A Comprehensive Review.

Specific properties of layered double hydroxides (LDHs), directions of their use as supports and support precursors for synthesis of catalysts, and advantages of using such catalysts for various reactions were considered. The possibility to vary the chemical composition of LDHs (cationic layers, interlayer space) without destroying the structure of the material allows tuning their adsorption and acid-base properties and selectively realizing various mechanisms of anchoring the active component precursor toward preparing highly dispersed and stable supported catalysts. Approaches to the formation of supported platinum particles with desired properties through changing the anionic and cationic compositions of LDHs were proposed for the Pt/MgAl(M)-LDH system taken as an example.

Oh Yeon-Ji

Papers

Anionic clay as a drug delivery vehicle