Osamu Komagata

TL;DR: In vivo metabolism studies showed that the SP strain excreted permethrin metabolites more rapidly than a susceptible SMK strain, and in vitro metabolism studies indicated an association of P450s with resistance, suggesting that cytochrome P450 monooxygenases (P450s) play an important role in resistance development.

TL;DR: The overall percentage of homozygous F1269C seems to remain low (7.4%) in the present situation, however, extensive and uncontrolled frequent use of photostable pyrethroids might be a strong selection pressure for this mutation to cause serious problems in the control of dengue fever in Vietnam.

TL;DR: In JPal-per, the transcription levels of CYP9M10 and CYP4H34 showed a similar stage-dependent pattern as a high expression level during the larvfrom Ogasawara Islands in Japanal stage dramatically decreases in the adult stage, suggesting that the two P450s are involved in pyrethroid detoxification in J Pal-per strain.

TL;DR: The Asian tiger mosquito, Aedes albopictus, is the major vector of Chikungunya fever and the secondary vector of dengue fever, and genotyping assay detects an amino acid substitution, F1534C, which is suspected to confer knockdown resistance to pyrethroid insecticides.

TL;DR: The results imply that pyrethroid insecticides are highly likely to lose their effectiveness against A. aegypti if such a Vssc haplotype emerges as the result of a single crossing-over event; thus, this may cause failure to control this key mosquito vector.