Summary Background Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described. Methods In this retrospective, multicentre cohort study, we included all adult inpatients (≥18 years old) with laboratory-confirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital (Wuhan, China) who had been discharged or had died by Jan 31, 2020. Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death. Findings 191 patients (135 from Jinyintan Hospital and 56 from Wuhan Pulmonary Hospital) were included in this study, of whom 137 were discharged and 54 died in hospital. 91 (48%) patients had a comorbidity, with hypertension being the most common (58 [30%] patients), followed by diabetes (36 [19%] patients) and coronary heart disease (15 [8%] patients). Multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1·10, 95% CI 1·03–1·17, per year increase; p=0·0043), higher Sequential Organ Failure Assessment (SOFA) score (5·65, 2·61–12·23; p Interpretation The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 μg/mL could help clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future. Funding Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences; National Science Grant for Distinguished Young Scholars; National Key Research and Development Program of China; The Beijing Science and Technology Project; and Major Projects of National Science and Technology on New Drug Creation and Development.

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

A review of the present and future utilisation of FRP composites in the civil infrastructure with reference to their important in-service properties

https://www.civil.iitb.ac.in/~tkant/papers/TKant-IITB-JP116.pdf

Application of polymer composites in civil construction : A general review

Fiber-reinforced polymer composites in strengthening reinforced concrete structures: A critical review

The use of high modulus CFRP laminates in strengthening steel members has the advantage of increasing the strength and stiffness of such members. In this paper, the bond characteristics between ultra high modulus (UHM) CFRP laminates with a modulus of 460 GPa and steel were studied. A series of experiments with double strap steel joints bonded with UHM CFRP laminates were conducted. Experimental results presented in this paper include failure modes, bond strength, effective bond length, CFRP strain distribution, adhesive layer shear stress distribution and bond slip relationship. Comparison was made with previous research on CFRP sheet–steel and normal modulus CFRP laminate–steel systems and different aspects of bond characteristics were discussed. Theoretical models were employed for the prediction of the specimen bond strength and effective bond length, and their applicability for UHM CFRP–steel joints was verified by comparisons with experimental results. Nonlinear finite element analysis was carried out to simulate the experimental specimens. The FEA results agreed well with those from experiments.

Oualid Limam

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