Anti-Infectives Agents Affecting the Central Nervous System Analgesics, Narcotic Antagonists and Agents Used to Treat Arthritis Agents Used in Anesthesia Gastrointestinal Agents Cardiac, Vascular, and Renal Agents Hormones and Agents Affecting Hormonal Mechanisms Agents Affecting Blood Formation and Coagulability Homeostatic and Nutrient Agents Agents Used to Treat Allergic and Neuromuscular Disorders Oncolytic Agents Heavy Metal Antagonists and Miscellaneous Agents Drugs Used Primarily in Ophthalmology Index of Side Effects

Drug-Induced Ocular Side Effects

The Effect of Intracameral Carbachol on Intraocular Pressure After Cataract Extraction

Carbachol instilled in 125 eyes at the time of extracapsular cataract extraction and posterior chamber lens insertion had a statistically significant effect on lowering the postoperative intraocular pressure (IOP) at 24 hours (average IOP 14.0 mm Hg) and at 72 hours (average IOP 11.6 mm Hg) (P less than .001). The percentage of patients with an acute IOP elevation at 24 hours was also significantly reduced: carbachol 10% versus control 33% (P = .001). Carbachol's prolonged lowering of postoperative IOP may increase the safety of cataract surgery, particularly in patients with compromised optic nerves.

Effect of carbachol on postoperative intraocular pressure

Injections of 0.01% carbachol and 1% acetylcholine chloride (Miochol) into the anterior chamber in round pupil cataract extractions prevent the formation of peripheral anterior synechia but do not preserve the integrity of the vitreous face. Carbachol (0.01%) is as effective for prompt miosis as acetylcholine (1.0%), but the miosis is more prolonged with carbachol.

Miotics in cataract surgery.

Determination of carbachol in aqueous solution.

Carbachol in a weak dilution (0.01%) is effective and relatively nonirritating when used as a miotic after the lens is removed in round pupil cataract extraction.

P R Belluscio

Papers

Carbachol in cataract surgery.