Recent advances in gene mapping technologies have led to increased emphasis in developing representative genetic maps for several species, particularly domestic plants and animals. These maps are being compiled with two distinct goals: to provide a resource for genetic analysis, and to help dissect the evolution of genome organization by comparing linkage relationships of homologous genes. We propose here a list of 321 reference anchor loci suitable for comparative gene mapping in mammals and other vertebrate classes. We selected cloned mouse and human functional genes spaced an average of 5–10 centiMorgans throughout their respective genomes. We also attempted to include loci that are evolutionary conserved and represented in comparative gene maps in other mammalian orders, particularly cattle and the domestic cat. We believe that the map may provide the basis for a unified approach to comparative analysis of mammalian species genomes.

Anchored reference loci for comparative genome mapping in mammals.

Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.

Comparative maps for mice and humans have been exceptionally important for predicting linkages, for identifying homologous mutations and disease loci, and for studying genome organization and evolution. This report summarizes the status of this comparative map. We provided a listing of homologous genes and anonymous loci that have been mapped in mice and humans together with references documenting homology and the chromosomal and linkage assignments (Table 1). We used a matrix to help readers find con-

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Comparative map for mice and humans.

https://www.cell.com/cell/pdf/0092-8674(85)90310-1.pdf

Transposition of the immunoglobulin heavy chain enhancer to the myc oncogene in a murine plasmacytoma.

Chromosome displays and listings are presented showing loci whose position is known in both man and mouse, in similar manner to our previous report (Dalton et al. 1981). There is now evidence for at least 27 conserved autosomal segments with two or more loci in the two species. The human and mouse chromosome maps show the location of homologous genes. The mouse map also shows the positions of translocations used in gene location and of some other genes used in linkage studies on them.

Chromosome maps of man and mouse

We have utilized a panel of Chinese hamster × mouse somatic cell hybrids segregating mouse chromosomes to assign a gene for arylsulfatase A (ARSA) to mouse chromosome 15. Considering our previous assi

Conserved autosomal syntenic group on mouse (MMU) chromosome 15 and human (HSA) chromosome 22: assignment of a gene for arylsulfatase A to MMU 15 and regional mapping of DIAl, ARSA, and ACO2 on HSA 22

P. Tetri

Papers

Conserved autosomal syntenic group on mouse (MMU) chromosome 15 and human (HSA) chromosome 22: assignment of a gene for arylsulfatase A to MMU 15 and regional mapping of DIAl, ARSA, and ACO2 on HSA 22