P
Padmanabhan Balaram
Researcher at Indian Institute of Science
Publications - 501
Citations - 17151
Padmanabhan Balaram is an academic researcher from Indian Institute of Science. The author has contributed to research in topics: Peptide & Helix. The author has an hindex of 63, co-authored 499 publications receiving 16563 citations. Previous affiliations of Padmanabhan Balaram include National Centre for Biological Sciences & Council of Scientific and Industrial Research.
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Parallel and antiparallel aggregation of alpha-helices. Crystal structures of two apolar decapeptides X-Trp-Ile-Ala-Aib-Ile-Val-Aib-Leu-Aib-Pro-OMe (X = Boc, Ac).
TL;DR: The structures do not provide a ready rationalization of packing preference in terms of side-chain interactions and do not support a major role for helix dipole interactions in determining helix orientation in crystals.
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Infrared spectroscopic study of C7 intramolecular hydrogen bonds in peptides
TL;DR: It is shown that Z‐Aib‐AIB‐OMe and Z‐ aib‐Ala‐OMes form C7 intramolecular hydrogen bonds in addition to C5 intramolescular hydrogen Bonds, and that all the peptides studied exist in more than one conformation in solution.
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A designed three-stranded β-sheet in an α/β hybrid peptide.
Rajesh Sonti,Hosahudya N. Gopi,Hosahudya N. Gopi,Umashankara Muddegowda,Srinivasarao Ragothama,Padmanabhan Balaram +5 more
TL;DR: The incorporation of β-amino acid residues into the antiparallel β-strand segments of a multi-stranded β-sheet peptide is demonstrated for a 19-residue peptide, supporting the occurrence of conformational interconversion at the turn segments in these hairpin and sheet structures.
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Cyclic peptide disulfides. solution and solid-state conformation of boc-cys-pro-aib-cys-nhme with a disulfide bridge from cys to cys, a disulfide-bridged peptide helix
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Rapid mass spectrometric determination of disulfide connectivity in peptides and proteins
TL;DR: The method, coupled with DisConnect, provides an unambiguous, straightforward approach, especially useful for the rapid screening of the disulfide crosslink fidelity in recombinant proteins, determination of disulfides linkages in natural peptide toxins and characterization of folding intermediates encountered in oxidative folding pathways.