Paola Parrella

TL;DR: These findings demonstrate for the first time that LKB1/STK11 inactivation is a very common event and may be integrally involved in the development of sporadic lung adenocarcinoma.

TL;DR: The high frequency of D310 alterations in primary breast cancer combined with the high sensitivity of the PCR-based assays provides a new molecular tool for cancer detection.

TL;DR: The identification of a specific and highly polymorphic homopolymeric C stretch (D310), located within the displacement (D) loop, as a mutational hotspot in primary tumors is presented and a model in which D310 alterations are already present in normal cells and achieve homoplasmy in the tumor through a restriction/amplification event attributable to random genetic drift and clonal expansion is proposed.

TL;DR: Low-dose fish oil supplementation has short-term and long-term normalizing effects on the abnormal rectal proliferation patterns associated with increased colon cancer risk.

TL;DR: The mutual exclusivity of M3 and 6p alterations suggests a bifurcated tumor progression model, in this model, M3 or 6p loss identify distinct pathways, both followed by 8q loss in tumor progression.