P
Paolo Governa
Researcher at University of Siena
Publications - 7
Citations - 51
Paolo Governa is an academic researcher from University of Siena. The author has contributed to research in topics: Magnolia officinalis & Proinflammatory cytokine. The author has an hindex of 2, co-authored 7 publications receiving 12 citations.
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Journal ArticleDOI
Cannabidiol Isolated From Cannabis sativa L. Protects Intestinal Barrier From In Vitro Inflammation and Oxidative Stress
Veronica Cocetta,Paolo Governa,Vittoria Borgonetti,Mattia Tinazzi,Gregorio Peron,Daniela Catanzaro,Massimiliano Berretta,Marco Biagi,Fabrizio Manetti,Stefano Dall'Acqua,Monica Montopoli +10 more
TL;DR: In this paper, the effects of different C. sativa isolated compounds in an in vitro model of intestinal epithelium were investigated and the ability of treatments to modulate markers of intestinal dysfunctions was tested on Caco-2 intestinal cell monolayers.
Journal ArticleDOI
FFAR1/GPR40: One target, different binding sites, many agonists, no drugs, but a continuous and unprofitable tug-of-war between ligand lipophilicity, activity, and toxicity.
Paolo Governa,Maria Cristina Caroleo,Gabriele Carullo,Francesca Aiello,Erika Cione,Fabrizio Manetti +5 more
TL;DR: The progress made so far in the elucidation of the structure of free fatty acid receptor 1 (FFAR1) and its secondary and ternary complexes with partial and full allosteric ligands led to the discovery of various putative binding regions on the FFAR1 surface as mentioned in this paper.
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Novel Therapeutic Approach for the Management of Mood Disorders: In Vivo and In Vitro Effect of a Combination of L-Theanine, Melissa officinalis L. and Magnolia officinalis Rehder & E.H. Wilson.
TL;DR: TMM showed an anxiolytic-like and antidepressant-like activity in vivo, which was related to a neuroprotective effect in an in vitro model of excitotoxicity, suggesting a non-benzodiazepine-like mechanism of action.
Journal ArticleDOI
A honokiol-enriched Magnolia officinalis Rehder & E.H. Wilson. bark extract possesses anxiolytic-like activity with neuroprotective effect through the modulation of CB1 receptor.
Vittoria Borgonetti,Paolo Governa,Fabrizio Manetti,Elisabetta Miraldi,Marco Biagi,Nicoletta Galeotti +5 more
TL;DR: In this article, a standardized M. officinalis bark extract (MOE), enriched in honokiol, and its effect on animal mood behavioural tests and in an in vitro model of excitotoxicity was evaluated.
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Anti-inflammatory activity of a fixed combination of probiotics and herbal extract in an in vitro model of intestinal inflammation by stimulating Caco-2 cells with LPS- conditioned THP-1 cells medium.
Vittoria Borgonetti,Veronica Cocetta,Marco Biagi,Ilaria Carnevali,Paolo Governa,Monica Montopoli +5 more
TL;DR: CKG is able to prevent the impairment of intestinal barrier function induced by inflammation, ameliorating the transepithelial electrical resistance and the paracellular permeability of the Caco-2 monolayer; moreover, CKG is ability to counteract the increased release of TNF-a and IL-8 induced by inflammatory stimulus, thus reducing the intestinal inflammation.