Parkhomenko IuM

TL;DR: The obtained data indicate that the active sites on SPM responsible for thiamine binding and ThTPase activity have different sensitivity toThiamine antagonists, which allow us to suppose that different active protein sites are responsible for the specific binding and for th Liamine phosphates hydrolysis by TBP of synaptic membranes.

TL;DR: The results of long-term complex studies by groups of authors give evidence on importance and urgency of formulation and execution of International program on optimisation of nutrition, micronutrition status and health among population of affected areas in Ukraine, Bielorus' and Russia.

TL;DR: It was shown that the active site of the enzyme that catalyzes the ThTP hydrolysis in neural cells plasma membranes is associated with the inside membrane surface.

TL;DR: The results of this investigation have shown that the part of metabolic changes caused by long-term usage of alcohol, can be caused by direct influence of ethanol or its metabolites on those or other enzymatic proteins or receptors, and their functions can quickly be normalized after the abolition of alcohol.

TL;DR: In this article, the role of thiamine in the synthesis of acethylcholine was investigated in rat brain and showed the presence of the regulation site on the enzyme distinguishing from the active enzyme centre and participating in the interaction with which the hydrophobic fragments of the Thiamine molecule participating.