Showing papers by "Patoomratana Tuchinda published in 1991"
TL;DR: Most of the isolates demonstrated cytotoxic activity when tested against cultured P-388 cells, with the flavans being more active than the flavones, and certain of these structurally related flavonoids exhibited somewhat selective activities when evaluated with a number of human cancer cell lines.
Abstract: From a cytotoxic Et2O-soluble extract of Muntingia calabura roots, twelve new flavonoids were isolated, constituting seven flavans 1-7, three flavones 8, 10, and 12, and two biflavans 9 and 11. The structures of compounds 1-12 were established by the interpretation of spectral data, with the nmr assignments of these constituents being based on 1H-1H COSY, 1H-13C HETCOR, and selective INEPT experiments. This is the first report of the occurrence of 7,8-di-O-substituted flavans, biflavans, and flavones. Most of the isolates demonstrated cytotoxic activity when tested against cultured P-388 cells, with the flavans being more active than the flavones. Furthermore, certain of these structurally related flavonoids exhibited somewhat selective activities when evaluated with a number of human cancer cell lines.
100 citations
TL;DR: All butenolides showed cytotoxic activities in several tumour cell lines and the structures of the isolated compounds were elucidated by spectroscopic methods.
33 citations