P
Patricia C. Edwards
Researcher at Medical Research Council
Publications - 3
Citations - 1836
Patricia C. Edwards is an academic researcher from Medical Research Council. The author has contributed to research in topics: G protein-coupled receptor & Membrane protein. The author has an hindex of 2, co-authored 3 publications receiving 1776 citations.
Papers
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Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
Søren G. F. Rasmussen,Hee Jung Choi,Daniel M. Rosenbaum,Tong Sun Kobilka,Foon Sun Thian,Patricia C. Edwards,Manfred Burghammer,Venkata R. P. Ratnala,Ruslan Sanishvili,Robert F. Fischetti,Gebhard F. X. Schertler,William I. Weis,Brian K. Kobilka +12 more
TL;DR: In this paper, the human beta2 adrenoceptor (beta2AR) was crystallized in a lipid environment when bound to an inverse agonist and in complex with a Fab that binds to the third intracellular loop.
Patent
Crystal structure of a betal -adremergi c receptor and uses thereof
Antony Johannes Warne,Maria Josefa Serrano-Vega,Rouslan Moukhametzianov,Patricia C. Edwards,Richard Henderson,Andrew G. W. Leslie,Christopher Gordon Tate,Gebhard F. X. Schertler +7 more
TL;DR: In this article, a method of predicting a 3D structural representation of a target protein of unknown structure, or part thereof, was proposed, comprising of providing the coordinates of the turkey β1-AR structure listed in Table A, Table B, Table C or Table D, optionally varied by a root mean square deviation of residue backbone atoms of not more than 1.235 A.
Crystal structures of the e 2 -adrenergic receptor
William I. Weis,Daniel M. Rosenbaum,Hee Jung Choi,Foon Sun Thian,Tong Sun Kobilka,Xiao-Jie Yao,Peter Day,Charles Parnot,Brian K. Kobilka,Vadim Cherezov,Michael A. Hanson,Peter Kuhn,Raymond C. Stevens,Patricia C. Edwards,Juan J. Fung +14 more
TL;DR: Two approaches were taken to obtain crystal structures of GPCRs that bind to diffusible ligands that have low natural abundance, are relatively unstable in detergents, and dis- play basal G protein activation even in the absence of ligands.