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Patrick J. Fleming
Researcher at Johns Hopkins University
Publications - 36
Citations - 2410
Patrick J. Fleming is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Bacterial outer membrane & Lipid bilayer. The author has an hindex of 23, co-authored 33 publications receiving 2172 citations.
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Journal ArticleDOI
A backbone-based theory of protein folding
TL;DR: Key ideas regarding protein folding developed over the past half-century are summarized and an alternative model that inverts the prevailing side-chain/backbone paradigm is proposed, which drives the chain to self-organize under folding conditions.
Journal ArticleDOI
Internal packing of helical membrane proteins
TL;DR: The tight helix packing revealed in this analysis contributes to membrane protein stability and likely compensates for the lack of the hydrophobic effect as a driving force for helix-helix association in membranes.
Journal ArticleDOI
Polyproline II helix is the preferred conformation for unfolded polyalanine in water
TL;DR: The simulations indicate that the solvation free energy of PII is favored over that of other conformers for reasons that defy conventional explanation.
Journal ArticleDOI
Do all backbone polar groups in proteins form hydrogen bonds
TL;DR: Evidence from proteins and peptides supports the conclusion that intrapeptide hydrogen bonds stabilize the folded form of proteins, and this realization establishes a powerful rule for evaluating protein conformations.
Book ChapterDOI
[8] Purification of cytochrome b5
TL;DR: The isolation of cytochrome b 5 from liver endoplasmic reticulum in its complete form requires fractionation procedures with detergents at 0° to avoid loss of peptide fragments by endopeptidase activity.