Showing papers by "Patrick J. Gallagher published in 1982"
TL;DR: Findings provide no support for the concept of cranial arteritis as a form of immune complex vasculitis, which may be a disease of disordered immunity.
Abstract: The cause of cranial arteritis is unknown, but the demonstration of immunoglobulin and complement in temporal artery biopsies by immunofluorescence suggest that it may be a disease of disordered immunity. Because of the inevitable problems of histologic interpretation associated with the fluorescent technique, 15 temporal artery biopsies from patients with active arteritis were examined by an immunoperoxidase method. Varying amounts of IgA, IgG, and IgM were identified in plasma cells and macrophages. Extracellular IgG was identified in 1 case, but there was no staining for complement. These findings provide no support for the concept of cranial arteritis as a form of immune complex vasculitis.
30 citations
14 citations
TL;DR: Aggregated IgG is frequently employed as a standard in systems for the measurement of immune complexes in man and animals and suggests that when used together they are capable of measuring immune complexes present over a wide range of sizes.
11 citations
TL;DR: Perinatal exposure to dietary antigen in rabbits may be important in modulating the systemic immune reaction to food antigens and may have an important influence on the development of aortic disease produced by prolonged feeding of high-fat, cholesterol-free diets.
6 citations