P
Paul A. Bartlett
Researcher at University of California, Berkeley
Publications - 209
Citations - 9176
Paul A. Bartlett is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Transition state analog & Thermolysin. The author has an hindex of 54, co-authored 209 publications receiving 8994 citations. Previous affiliations of Paul A. Bartlett include Lawrence Berkeley National Laboratory & University of California.
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Stereocontrol in the synthesis of acyclic systems: applications to natural product synthesis
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Phosphorus amino acid analogues as inhibitors of leucine aminopeptidase.
TL;DR: The fact that tetrahedral phosphorus analogues are less potent inhibitors of LAP than they are of other zinc peptidases suggests that the mechanism of L AP may be fundamentally different than that of the latter enzymes.
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CAVEAT: a program to facilitate the design of organic molecules.
Georges Lauri,Paul A. Bartlett +1 more
TL;DR: The focus in this report is the design and implementation of the principal algorthms and the performance achieved in the program CAVEAT.
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Binding Energy and Catalysis: The Implications for Transition-State Analogs and Catalytic Antibodies.
Mary M. Mader,Paul A. Bartlett +1 more
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Phosphonamidates as transition-state analogue inhibitors of thermolysin.
TL;DR: The correlation noted between inhibitor Ki and substrate Km/kcat is the most extensive one of this type, providing strong evidence that the phosphonamidates are transition- state analogues and not simply multisubstrate ground-state analogues.