A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.

System and method for determining an abused sensor during analyte measurement

The present invention provides a test strip for measuring a concentration of an analyte of interest in a biological fluid, wherein the test strip may be encoded with information that can be read by a test meter into which the test strip is inserted.

System and method for coding information on a biosensor test strip

Bar code information is printed on a printable surface associated with a product, such as a label or container of the product, or the product itself, during a production run under the control of a printer computer. The bar code information may include two components of a composite bar code symbol, where the first component is either pre-printed or printed during a production run, and the second component is printed during the production run. The first component may identify a product that is carried in the containers, while the second component identifies a lot, batch, expiration date or commodity number. In another aspect, check data is used to confirm the accuracy of information that is used by a printer computer to control a printer. In another aspect, first and second bar code symbols portions are read to recover information, and a database is accessed to determine if the recovered information is consistent.

Method and apparatus for applying bar code information to products during production

System and method for analyte measurement using ac excitation

System and method for analyte measurement using dose sufficiency electrodes

There is described a method of barcoding data needed to determine a calibration curve for a test element in an analyzer The process follows the steps of: a) ascertaining by statistical analysis the ranges of values for R that are possible for three given concentration values C1, C2 and C3, for a given assay, and assigning a high value H and a low value L for these ranges; b) calculating for a given lot of the given assay, a calibration curve that correlates the analyzer response to the concentration, c) determining the analyzer response R1, R2 and R3 from said calibration curve, that corresponds to the C1, C2 and C3 values; d) calculating the bar code value B1 for Ri of each of these R1, R2 and R3 from the equation: (2) Bi = (10n - 1)(Ri - Li)/ (Hi-Li) where Ri is R1, R2 or R3, and Li and Hi are the corresponding L and H values for that Xi; e) rounding Bi to the nearest integer;and f) supplying this value of Bi for each of Ri = R1, R2 or R3 in bar code form, using n-digit decimal numbers, so that only three sets of (10n) possibilities are needed to accurately pass along data corresponding to the calibration coefficients even though each of the three coefficients can vary by more than that which can be specified using 10n digits

Bar coding calibration

It is known that there are differences in correlation between detected response and analyte concentration for test elements which are analyzed on different analyzers. These differences in correlation necessitate different calibration curves for each analyzer. Described herein is a method of calibrating an analyzer in the field, using parameters designed for a "standard" analyzer which may be different from the field analyzer. In this way, it is not necessary to use only certain slide elements of a given chemistry on one analyzer, and certain other slide elements of that same chemistry on another analyzer. Instead, the slide elements are made interchangeable by calibration mathematics which allow the field analyzer to convert its raw response RF into a response Rstandard of the selected "standard" analyzer, using the equation: Rstandard = B₀ + B₁.RF + B₂.(RF)k The coefficients of this equation are established by comparing, at at least 1 different level of response, RF against Rstandard, optionally using an intermediate spline function gF(RF) in place of RF.

Normalizing analyzer systems to a standard analyzer

A method of assaying analytes using a rate procedure is described where the change in density over time has a variable rate. The method features the steps of depositing the sample on to a dried slide-like test element, making an initial rate reading during an early time window, using the initial rate readings in a comparison study with rates from known low and high concentration results to predict whether the sample rate will be sufficiently low as to be ascertainable during a later time window or not, and then calculating a rate of reaction and concentration during either the early time window or the early time window with a portion of the later time window respectively. To avoid the possibility of a consistent bias, the initial rate readings are used directly in the comparison study without first calculating a concentration, by comparing the initial rate reading of a sample against known rates corresponding to samples with low and high concentrations to determine the length of the time window to be used in the rate calculation.

A method for reaction rate determination of analytes

A method of assaying analytes using a rate procedure is described where the change in density over time has a variable rate. The method features the steps of depositing the sample onto a dried slide-like test element, making an initial rate reading during an early time window, using the initial rate readings in a comparison study with rates from known low and high concentration results to predict whether the sample rate will be sufficiently low as to be ascertainable during a later time window or not, and then calculating a rate of reaction and concentration during either the early time window or the early time window with a portion of the later time window, respectively. To avoid the possibility of a consistent bias, the initial rate readings are used directly in the comparison study without first calculating a concentration, by comparing the initial rate reading of a sample against known rates corresponding to samples with low and high concentrations to determine the length of the time window to be used in the rate calculation.

Paul Arthur C

Papers

Bar coding calibration

Normalizing analyzer systems to a standard analyzer

A method for reaction rate determination of analytes

Windowing in rate assays without using initial predicted concentration

Verfahren zur Reaktionsgeschwindigkeitsmessung von Analyten