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Showing papers by "Paul Bamborough published in 2006"

Journal Article•DOI•
5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase

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Paul Bamborough1, John A. Christopher1, Geoffrey J. Cutler1, Marion C. Dickson1, Geoffrey W. Mellor1, James V. Morey1, Champa Patel1, Lisa M. Shewchuk2 •
GlaxoSmithKline1, Research Triangle Park2
15 Dec 2006-Bioorganic & Medicinal Chemistry Letters
TL;DR: In this article, the identification and hit-to-lead exploration of a novel, potent and selective series of substituted benzimidazole-thiophene carbonitrile inhibitors of IKK-e kinase is described.

49 citations

Patent•
Nicotinamide Derivatives Useful as p38 Inhibitors

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Aston Nicola Mary, Paul Bamborough, Walker Ann Louise
07 Aug 2006
TL;DR: The p38 inhibitors of formula (I) are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 activity or mediated by cytokines produced by the activity of P38 as discussed by the authors.
Abstract: Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.

9 citations