P
Paul L. Feldman
Researcher at Research Triangle Park
Publications - 80
Citations - 2990
Paul L. Feldman is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Phosphodiesterase & Arginine. The author has an hindex of 29, co-authored 80 publications receiving 2794 citations. Previous affiliations of Paul L. Feldman include GlaxoSmithKline.
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Journal ArticleDOI
Nitric Oxide: A New Paradigm for Second Messengers
Journal ArticleDOI
Design, synthesis, and pharmacological evaluation of ultrashort- to long-acting opioid analgetics.
Paul L. Feldman,Michael K. James,Marcus F. Brackeen,J M Bilotta,S V Schuster,A P Lahey,Michael W. Lutz,M R Johnson,H J Leighton +8 more
TL;DR: It was demonstrated that the duration of action for the ultrashort-acting analgetic, 8, does not change upon prolonged infusion or administration of multiple bolus injections, and the SAR with respect to analgesic activity andduration of action as a function of the various esters synthesized is discussed.
Journal ArticleDOI
CNS 7056: a novel ultra-short-acting Benzodiazepine.
Gavin J. Kilpatrick,Margaret S McIntyre,Richard F. Cox,Jeffrey A. Stafford,Gregory J Pacofsky,Gwyer G Lovell,Robert P. Wiard,Paul L. Feldman,Holly A. Collins,Barbara L. Waszczak,Gary Stuart Tilbrook +10 more
TL;DR: Inhibition of substantia nigra pars reticulata firing and the inhibition of the effects of CNS 7056 by flumazenil show that it acts at the brain benzodiazepine receptor.
Journal ArticleDOI
Intramolecular nitrogen-hydrogen, oxygen-hydrogen and sulfur-hydrogen insertion reactions. Synthesis of heterocycles from .alpha.-diazo .beta.-keto esters
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Irreversible inactivation of macrophage and brain nitric oxide synthase by L-NG-methylarginine requires NADPH-dependent hydroxylation.
TL;DR: The data suggest that enzyme inhibition occurs as a consequence of oxidative metabolism of the intermediate, NOHNMA, which accounts for NO biosynthesis from ARG, for the inactivation of NOS by NMA and for the intermediacy of hydroxylated ARG or NMA derivatives in these processes.