P
Paul Rigby
Researcher at University of Western Australia
Publications - 92
Citations - 3396
Paul Rigby is an academic researcher from University of Western Australia. The author has contributed to research in topics: Endothelin receptor & Respiratory tract. The author has an hindex of 29, co-authored 92 publications receiving 3096 citations. Previous affiliations of Paul Rigby include Princess Margaret Hospital for Children & Australian Institute of Marine Science.
Papers
More filters
Journal ArticleDOI
Vascular normalization in Rgs5-deficient tumours promotes immune destruction
Juliana Hamzah,Manfred Jugold,Fabian Kiessling,Paul Rigby,Mitali Manzur,Hugo H. Marti,Tamer Rabie,Sylvia Kaden,Hermann Josef Gröne,Günter J. Hämmerling,Bernd Arnold,Ruth Ganss +11 more
TL;DR: This is the first demonstration, to the authors' knowledge, of reduced tumour angiogenesis and improved immune therapeutic outcome on loss of a vascular gene function and establishes a previously unrecognized role of G-protein signalling in tumourAngiogenesis.
Journal ArticleDOI
Influence of the epithelium on responsiveness of guinea-pig isolated trachea to contractile and relaxant agonists.
TL;DR: It was concluded that the reduced functional response of guinea‐pig trachea to isoprenaline was probably not due to smooth muscle β‐adrenoceptor dysfunction, and results indicate that the epithelium plays an important role in the modulation of responsiveness of Guinea‐ pig trachesa to histamine and relaxants that mediate their effects by selectively increasing intracellular cyclic AMP levels.
Journal ArticleDOI
Interaction between Burkholderia pseudomallei and Acanthamoeba species results in coiling phagocytosis, endamebic bacterial survival, and escape.
Timothy J. J. Inglis,Paul Rigby,Terry Robertson,Nichole Dutton,Mandy Henderson,Barbara J. Chang +5 more
TL;DR: Demonstration of an interaction between B. pseudomallei and free-living acanthamebae in vitro raises the possibility that a similar interaction in vivo might affect environmental survival of the species and warrant further investigation.
Journal ArticleDOI
Endothelin-1-induced potentiation of human airway smooth muscle proliferation: an ETA receptor-mediated phenomenon.
TL;DR: The findings suggest that ET‐1, a mediator detected in increased amounts in patients with acute asthma, may potentiate the proliferative effects of mitogens and contribute to the airway smooth muscle hyperplasia associated with chronic severe asthma.
Journal ArticleDOI
Multi-species bacterial biofilm and intracellular infection in otitis media
Ruth B. Thornton,Ruth B. Thornton,Paul Rigby,Selma P. Wiertsema,Selma P. Wiertsema,Pierre Filion,Jennifer Langlands,Harvey Coates,Harvey Coates,Shyan Vijayasekaran,Shyan Vijayasekaran,Anthony D. Keil,Peter Richmond,Peter Richmond +13 more
TL;DR: Using FISH and CLSM, bacterial biofilm and intracellular infection with known otopathogens are demonstrated on/in the middle ear mucosa of children with COME and/or rAOM.