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Paula J. Brunton
Researcher at University of Edinburgh
Publications - 75
Citations - 3636
Paula J. Brunton is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Prenatal stress & Offspring. The author has an hindex of 31, co-authored 72 publications receiving 3168 citations. Previous affiliations of Paula J. Brunton include Zhejiang University & The Roslin Institute.
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Journal ArticleDOI
The expectant brain: adapting for motherhood
Paula J. Brunton,John A. Russell +1 more
TL;DR: A successful pregnancy requires multiple adaptations of the mother's physiology to optimize fetal growth and development, to protect the fetus from adverse programming, to provide impetus for timely parturitions and to ensure that adequate maternal care is provided after parturition.
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The consequences of early life adversity: neurobiological, behavioural and epigenetic adaptations
TL;DR: What is known about the neurobiological and epigenetic mechanisms that underpin early‐life programming of the neonatal brain in the first generation and subsequent generations are discussed, with a view to abrogating programming effects and potentially identifying new therapeutic targets for the treatment of stress‐related disorders and cognitive impairment.
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Adaptive Responses of the Maternal Hypothalamic-Pituitary-Adrenal Axis during Pregnancy and Lactation
TL;DR: The mechanism of reduced CRF neurone responses to physical stressors in pregnancy is the suppression of noradrenaline release in the PVN by an up‐regulated endogenous opioid mechanism, which is induced by neuroactive steroid produced from progesterone.
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Prenatal Social Stress in the Rat Programmes Neuroendocrine and Behavioural Responses to Stress in the Adult Offspring: Sex-Specific Effects
Paula J. Brunton,John A. Russell +1 more
TL;DR: The data obtained in the present study indicate that prenatal social stress differentially programmes anxiety behaviour and HPA axis responses to stress in male and female offspring.
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Effects of maternal exposure to social stress during pregnancy: consequences for mother and offspring
TL;DR: Prenatal social stress also programmes future maternal behaviour, highlighting the potential for negative phenotypes to be transmitted to future generations and the potential to overwrite programming of the offspring.