P
Pekka Talke
Researcher at University of California, San Francisco
Publications - 76
Citations - 3784
Pekka Talke is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Dexmedetomidine & Hemodynamics. The author has an hindex of 32, co-authored 75 publications receiving 3542 citations. Previous affiliations of Pekka Talke include Wake Forest University & University of Texas Medical Branch.
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Journal ArticleDOI
The Hemodynamic and Adrenergic Effects of Perioperative Dexmedetomidine Infusion after Vascular Surgery
Pekka Talke,Richard T. Chen,Brian J. Thomas,Anil Aggarwall,Alexandru Gottlieb,Per Thorborg,Stephen O. Heard,Albert T. Cheung,Stanley Lee Son,Antero Kallio +9 more
TL;DR: It is concluded that dexmedetomidine attenuates increases in heart rate and plasma norepinephrine concentrations during emergence from anesthesia in vascular surgery patients.
Journal ArticleDOI
Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine.
TL;DR: It is concluded that infusion of dexmedetomidine by CCIP using published pharmacokinetic parameters overshoots target plasma dexmedetic concentrations during the early postoperative period and heart rate, blood pressure, and plasma catecholamine concentrations decrease during dexmedettomidine infusion.
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Subthalamic nucleus deep brain stimulator placement using high-field interventional magnetic resonance imaging and a skull-mounted aiming device: technique and application accuracy.
TL;DR: The authors' technical approach to placement of DBS electrodes adapts the procedure to a standard configuration 1.5-T diagnostic MR imaging scanner in a radiology suite and simplifies DBS implantation by eliminating the use of the traditional stereotactic frame and the subsequent requirement for registration of the brain in stereotaxis space.
Journal ArticleDOI
Effects of Perioperative Dexmedetomidine Infusion in Patients Undergoing Vascular Surgery
Pekka Talke,Juliet Li,Uday Jain,Jacqueline M. Leung,Kenneth Drasner,Milton Hollenberg,Dennis T. Mangano +6 more
TL;DR: Infusion of dexmedetomidine up to a targeted plasma concentration of 0.45 ng/ml appears to benefit perioperative hemodynamic management of surgical patients undergoing vascular surgery but required greater intraoperative pharmacologic intervention to support blood pressure and heart rate.
Journal ArticleDOI
Dexmedetomidine Does Not Alter the Sweating Threshold, But Comparably and Linearly Decreases the Vasoconstriction and Shivering Thresholds
Pekka Talke,Farzin Tayefeh,Daniel I. Sessler,Renee Jeffrey,Mojtaba Noursalehi,Charles A. Richardson +5 more
TL;DR: Dexmedetomidine markedly increased the range of temperatures not triggering thermoregulatory defenses and is likely to promote hypothermia in a typical hospital environment; it is also likely to prove an effective treatment for shivering.