Isolation and analysis of ginseng: advances and challenges

Traditional uses, botany, phytochemistry, pharmacology and toxicology of Panax notoginseng (Burk.) F.H. Chen: A review.

Saponins in the genus Panax L. (Araliaceae): A systematic review of their chemical diversity

Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir (ACV) and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections, especially in immunocompromised patients. There is an urgent need to explore new and effective tactics to circumvent drug resistance to HSV. This review summarises the current strategies in the development of new targets (the DNA helicase/primase (H/P) complex), new types of molecules (nature products) and new antiviral mechanisms (lethal mutagenesis of Janus-type nucleosides) to fight the drug resistance of HSV.

/pdf/new-strategies-against-drug-resistance-to-herpes-simplex-2dzucipkqd.pdf

New strategies against drug resistance to herpes simplex virus

Terpenoids, the most abundant compounds in natural products, are a set of important secondary metabolites in plants with diverse structures. Terpenoids play key roles in plant growth and developmen...

https://journals.sagepub.com/doi/pdf/10.1177/1934578X20903555

Advances in Pharmacological Activities of Terpenoids

The invention relates to a pharmaceutical composition with dammarane-type tetracyclic triterpene compound as an active component and an application thereof to the pharmaceutical field. Panax notoginseng is separated to obtain three dammarane-type tetracyclic triterpene compounds as shown in the following structural formula, in vitro pharmacological experiments show that the pharmaceutical composition has good in vitro inhibitory activity for herpes simplex virus type I and can be applied to the preparation of medicines for resisting herpes simplex virus type I and is used for treating herpetic keratitis, encephalitis, pneumonia, ulcerative stomatitis, blister and the like caused by herpes simplex virus type I.

Anti-herpes simplex virus I-form medicament composition and uses thereof

The invention relates to a pharmaceutical composition with dammarane-type tetracyclic triterpene compound ginsenoside Rh4 as shown in the following structural formula and 20(S)-protopanaxatriol as the active components and the application thereof to the pharmaceutical field. The in vitro pharmacological experiments show that the pharmaceutical composition has good in vitro inhibitory activity for coxsackie B3 virus and can be used for treating viral myocarditis caused by coxsackie B3 virus.

Pengying Liao

Papers

Anti-herpes simplex virus I-form medicament composition and uses thereof

Anti-coxsackie medicament composition and medicine use thereof