Showing papers by "Per Venge published in 1978"
TL;DR: Inhalation challenge test was performed in 12 patients with bronchial asthma and the subsequent variation in blood cosinophils and serum-eosinophil cationic protein was followed up as mentioned in this paper.
Abstract: Inhalation challenge test was performed in 12 patients with bronchial asthma. The subsequent variation in blood cosinophils and serum-eosinophil cationic protein was followed up. Uniform patterns in both parameters were seen suggesting active participation of the eosinophil leucocyte in allergic inflammation.
130 citations
TL;DR: During the early course of infection there was a profound but reversible decrease of intraneutrophilic lactoferrin and the ‘eosinophil’ cationic proteins of serum were increased on the first day of infection, which may reflect increased eosinophile turnover.
Abstract: The intraneutrophilic concentrations of lactoferrin, myeloperoxidase, collagenase and chymotrypsin-like cationic proteins were measured sequentially during acute bacterial infection. The serum levels of lactoferrin and myeloperoxidase were also followed as well as the ‘eosinophil’ cationic protein as a marker for eosinophil leucocytes. During the early course of infection there was a profound but reversible decrease of intraneutrophilic lactoferrin. The levels of cellular collagenase and chymotrypsin-like cationic proteins also tended to decrease reversibly during day 2–8 in most cases; myeloperoxidase levels were normal except for two cases. Serum myeloperoxidase and lactoferrin correlated with blood neutrophil counts. In spite of the absence of peripheral eosinophils the ‘eosinophil’ cationic proteins of serum were increased on the first day of infection, which may reflect increased eosinophil turnover.
72 citations
Journal Article•
TL;DR: Beta-2-adrenergic drugs, salbutamol and terbutaline, had an eosinopenic effect and were able to decrease S-ECP concentration, indicating that only the adrenergic stimulators affect leucocyte secretion.
Abstract: The in vivo effect of beta-2-adrenergic stimulating and blocking drugs and of corticosteroid medication on blood eosinophils and serum eosinophil cationic protein (S-ECP) has been studied. The beta-2-adrenergic drugs, salbutamol and terbutaline, had an eosinopenic effect. They were able to decrease S-ECP concentration, which administration of steroid was not, indicating that only the adrenergic stimulators affect leucocyte secretion. Care must be taken in interpretation of blood eosinophil count and S-ECP concentration, and the actual medical treatment must be known.
27 citations
Journal Article•
TL;DR: Normal subjects and patients with bronchial asthma showed a similar diurnal variation in blood eosinophil count and serum eosInophil cationic protein concentration and it is concluded that this may result from a difference in hormonal or other influences.
Abstract: Normal subjects and patients with bronchial asthma showed a similar diurnal variation in blood eosinophil count and serum eosinophil cationic protein concentration. The blood eosinophils showed the highest count during the night whereas serum eosinophil cationic protein showed the highest concentration in the early evening. It is concluded that this may result from a difference in hormonal or other influences.
12 citations
Journal Article•
TL;DR: Using a solid-phase radioimmunoassay for detection of serum myoglobin, the pattern of myoglobinemia was investigated in patients with acute myocardial infarction, supporting the idea that the detection of myoglobin in serum may be a useful diagnostic aid in the qualitative diagnosis of myocardia infarct.
Abstract: Using a solid-phase radioimmunoassay for detection of serum myoglobin, the pattern of myoglobinemia was investigated in patients with acute myocardial infarction. All patients with acute infarcts had a marked rise in serum myoglobin concentration. Peak serum myoglobin concentration was found on an average 9 h after the initial onset of chest pain. Late onset of myoglobin peaks without signs of reinfarction as well as sustained abnormal myoglobinemia, in the majority of patients, could be explained by impaired renal function. The peak serum level of myoglobin correlated (r = 0.92) to the peak level of ASAT supporting the idea that the detection of myoglobin in serum may be a useful diagnostic aid in the qualitative diagnosis of myocardial infarction.
10 citations
TL;DR: Eosinophil cationic protein was estimated after extraction of the cells and a similar content was found in cells from both groups, suggesting a low intracellular content in patients with bronchial asthma.
Abstract: Eosinophil cationic protein constitutes a major part of eosinophil leucocyte granule protein. Low serum concentrations have previously been found in patients with bronchial asthma. As this might reflect a low intracellular content, eosinophils were isolated from normal controls and patients with bronchial asthma. Eosinophil cationic protein was estimated after extraction of the cells and a similar content was found in cells from both groups.
8 citations