Showing papers by "Peter A. Akah published in 2021"

Inhibition of oxidative stress and gastric emptying as additional mechanisms of antidiabetic activity of Newbouldia laevis

Abstract: The quest to fill the gap in knowledge about the antidiabetic activity of the leaf extract of Newbouldia laevis has inspired further exploration of its possible mechanisms of antidiabetic action. This study investigated inhibitions of oxidative stress and gastric emptying as additional mechanisms of antidiabetic activity of N. laevis. Antidiabetic activity of the ethanol extract was authenticated using a Streptozotocin-Nicotinamide-induced type 2 diabetic model. In vitro antioxidant potentials of the extract and fraction were evaluated using the total phenolic content and DPPH test while in vivo effect determined in CCL4 induced oxidative stress model using Silymarin as standard. The effect of the extracts and fractions on gastric emptying was determined using the extent of non-absorbable phenol red transit through the stomach. Treatment with 400 mg/kg of the extract produced significant (p