Peter E. Andreotti

TL;DR: An ATP luminescence assay (TCA 100) was used to measure chemotherapeutic drug sensitivity and resistance of dissociated tumor cells cultured for 6 days in serum-free medium and 96-well polypropylene microplates and indicates that the assay has > 90% accuracy for cisplatin resistance of ovarian carcinoma.

TL;DR: Vit C both at non-cytotoxic and moderately cytotoxic concentrations improved the cytotoxicity of DOX, DDP, and Tx significantly, and combination effects were partly synergistic and partly additive or subadditive whereas a consistent synergism was found between Vit C and DOX.

TL;DR: First results of ATP assay-directed chemotherapy in patients with ROC compare favorably with chemotherapy chosen by a clinician and often leads to the choice of novel drug combinations and warrant confirmation by prospective randomized trials.

TL;DR: A short-term cell culture assay based on the detection of ATP by the luciferin-luciferase reaction that has shown considerable promise as a general in vitro toxicity assay allowing both cell lines and primary tissue cultures to be tested.

TL;DR: Results from a newly developed tumor chemosensitivity assay (TCA) have been correlated prospectively with patient response, suggesting that it is capable of predicting outcome in individual patients.