P
Peter F. Hall
Researcher at Worcester Foundation for Biomedical Research
Publications - 111
Citations - 6188
Peter F. Hall is an academic researcher from Worcester Foundation for Biomedical Research. The author has contributed to research in topics: Pregnenolone & Cytochrome. The author has an hindex of 41, co-authored 111 publications receiving 6113 citations. Previous affiliations of Peter F. Hall include Hoshi University & University of Melbourne.
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Journal ArticleDOI
Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues.
Bon Chu Chung,James Picado-Leonard,Mitsuru Haniu,Michael J. Bienkowski,Peter F. Hall,John E. Shively,Walter L. Miller +6 more
TL;DR: RNA gel blots and nuclease S1-protection experiments confirm that the adrenal and testicular P450c17 mRNAs are indistinguishable, and indicate that the testis possesses a P 450c17 identical to that in the Adrenal.
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Microsomal cytochrome P-450 from neonatal pig testis: two enzymatic activities (17 alpha-hydroxylase and c17,20-lyase) associated with one protein.
TL;DR: It is concluded that a single heme protein (cytochrome P-450) from microsomes of neonatal pig testis catalyzes two reactions (hydroxylase and lyase) which are sequential steps in the synthesis of androgens by the testis leading to conversion of C21 precursors to C19 steroid hormones.
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Microsomal cytochrome P-450 from neonatal pig testis. Purification and properties of A C21 steroid side-chain cleavage system (17 alpha-hydroxylase-C17,20 lyase).
Shizuo Nakajin,Peter F. Hall +1 more
TL;DR: The studies raise the possibility that one microsomal protein (cytochrome P-450) may possess two enzymatic activities (hydroxylase and lyase) that require NADPH and a flavoprotein P- 450 reductase.
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Effect of luteinizing hormone deprivation in situ on steroidogenesis of rat Leydig cells purified by a multistep procedure.
TL;DR: Results show that Leydig cells from animals deprived of LH had diminished capacity to convert pregnenolone to testosterone and reduced P450 C17-hydroxylase/C17,20-lyase content.
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Identification of des-(Gly-Ile)-endozepine as an effector of corticotropin-dependent adrenal steroidogenesis: stimulation of cholesterol delivery is mediated by the peripheral benzodiazepine receptor
Marc J. Besman,Kazutoshi Yanagibashi,Terry D. Lee,Masahiro Kawamura,Peter F. Hall,John E. Shively +5 more
TL;DR: Diazepam effects a stimulation of adrenal mitochondrial cholesterol delivery similar to that observed for endozepine, suggesting that the mediation of corticotropin-induced steroidogenesis may be the physiological function of the peripheral-type benzodiazepine receptor.