The present invention is directed to collagen membranes having physical and biological properties which make them extremely suitable and desirable for all types of medical uses, particularly as a periodontal barrier. The membranes are characterized by having a surface roughness morphology similar to leather and are translucent. Moreover, these membranes do not swell appreciably upon being wetted so as to maintain their overall bulk density. Methods for preparing these membranes and applications for their use are also disclosed.

Dense collagen membrane matrices for medical uses

Microspheres of hydroxyapatite/reconstituted collagen as supports for osteoblast cell growth

Osteogenic compositions, and methods for preparing same, which compositions comprise a porous or semi-porous matrix, an osteogenic factor and an agent such as growth factors, nutrient factors, drugs, calcium-containing compounds, blood products, large molecular weight proteins, or combinations thereof. These materials can be used in a wide range of clinical procedures to replace and restore osseous or periodontal defects.

Compositions with enhanced osteogenic potential, methods for making the same and uses thereof

A novel processing technique is reported to bond non-woven fibers and, thus, prepare structural interconnecting fiber networks with different shapes for organ implants. The fibers are physically joined without any surface or bulk modification and have their initial diameter.

Preparation of bonded fiber structures for cell implantation

A transplantable artificial tissue matrix structure containing viable cells which is suitable for insertion into the body is made by polymerizing precursors in an aqueous solution to form a shape retaining solid matrix comprising viable cells, matrix polymer and reversible gel polymer. The solution contains a matrix polymer precursor, a reversible gel polymer precursor, and viable cells. The reversible gel polymer is dissolved and removed to yield an insoluble, porous matrix containing viable cells. The conditions and reagents are selected to maintain the viability of the cells. The invention is particularly suitable for artificial transplant matrix tissue containing pancreatic islet cells.

Transplantable artificial tissue and process

Weighted collagen microsponges having a highly crosslinked collagen matrix are described suitable for use in culturing organisms in motive reactor systems. The microsponges have an open to the surface pore structure, and pore sizes and volumes suitable for immobilizing a variety of bioactive materials. The microsponges also have an average particle size in the range of about 100 to about 1000 microns and a specific gravity above about 1.05.

Weighted collagen microsponge for immobilizing bioactive material

A fluidized bed reactor and reaction process, particularly well-suited for culturing cells, for example, for tissue culture and fermentation processes, are described which involve the treatment of at least a portion of the fluid exiting the fluidized bed reactor in a side loop in a manner to alter its temperature or composition, e.g., oxygenation, with recirculation of this treated fluid to the reactor as a portion of the fluid causing bed fluidization.

Fluidized cell cultivation process

Weighted microsponges preferably having a highly crosslinked collagen matrix suitable for use in culturing organisms in motive reactor systems. The microsponges have an open to the surface pore structure, and pore sizes and volumes suitable for immobilizing a variety of bioactive materials. The microsponges also have an average particle size in the range of about 100 to about 1000 microns and a specific gravity above about 1.05. Also described is an in vitro method for culturing organisms immobilized on a microsponge comprising a highly crosslinked, porous collagen matrix prepared by crosslinking Type I, II or III type collagen using a carbodiimide or a succinimidyl active ester and/or severe dehydration conditions.

Weighted microsponge for immobilizing bioactive material

Straight Channel Diffuser Performance at High Inlet Mach Numbers

: The results of a review and distillation of the fluid dynamic information gained during a program to develop superior high-pressure-ratio compressors for small gas turbine service are reported. The objectives were to critically test the design flow models proposed by Welliver and Acurio (1967), to improve these models where feasible, and then to redesign the compressor with concrete guidelines for reaching the U. S. Army Aviation Materiel Laboratories (USAAVLABS) target of pressure ratio 10 and 80% total to static stage efficiency at 2 lbm/sec flow.

Peter W. Runstadler

Papers

Weighted collagen microsponge for immobilizing bioactive material

Fluidized cell cultivation process

Weighted microsponge for immobilizing bioactive material

Straight Channel Diffuser Performance at High Inlet Mach Numbers

Fluid Mechanics Analysis of High-Pressure-Ratio Centrifugal Compressor Data