P
Phang C. Tai
Researcher at Georgia State University
Publications - 124
Citations - 3432
Phang C. Tai is an academic researcher from Georgia State University. The author has contributed to research in topics: Support vector machine & Signal peptide. The author has an hindex of 35, co-authored 123 publications receiving 3272 citations.
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Journal ArticleDOI
Misread protein creates membrane channels: an essential step in the bactericidal action of aminoglycosides
TL;DR: Evidence is presented that incorporation of misread proteins into the membrane can account for the membrane damage and imply that normal membrane proteins must be selected not only for a hydrophobic anchoring surface, but also for a tight fit in the membrane.
Journal ArticleDOI
ATP is essential for protein translocation into Escherichia coli membrane vesicles.
Lingling Chen,Phang C. Tai +1 more
TL;DR: It is concluded that ATP is required for protein translocation in this posttranslational system (and probably also in cotranslational translocation); the protonmotive force may contribute but does not appear to be essential.
Journal ArticleDOI
Cloning, characterization and expression of escapin, a broadly antimicrobial FAD-containing L-amino acid oxidase from ink of the sea hare Aplysia californica.
Hsiuchin Yang,Paul Johnson,Paul Johnson,Ko-Chun Ko,Michiya Kamio,Markus W. Germann,Charles D. Derby,Phang C. Tai +7 more
TL;DR: It is suggested that there are multiple mechanisms to escapin's antimicrobial effects, with bacteriostasis resulting largely or entirely from the effects of hydrogen peroxide produced by escapIn's LAAO activity, but bactericidal effects resulting from lysine-dependent mechanisms not directly involving hydrogenperoxide.
Journal ArticleDOI
Improved K-means clustering algorithm for exploring local protein sequence motifs representing common structural property
TL;DR: Experimental results indicate that the improved K-means algorithm generates more detailed sequence motifs representing common structures than previous research, and may be applied to other areas of bioinformatics research in order to explore the underlying relationships between data samples more effectively.
Journal ArticleDOI
Nonclassical Protein Secretion by Bacillus subtilis in the Stationary Phase Is Not Due to Cell Lysis
Chun-Kai Yang,Hosam E. Ewis,Xiao-Zhou Zhang,Xiao-Zhou Zhang,Chung-Dar Lu,Hae-Jin Hu,Hae-Jin Hu,Yi Pan,Ahmed T. Abdelal,Ahmed T. Abdelal,Phang C. Tai +10 more
TL;DR: It is concluded that the secretion of Est55 and several cytoplasmic proteins without signal peptides in B. subtilis is a general phenomenon and is not a consequence of cell lysis or membrane shedding; instead, their secretion is through a process(es) in which protein domain structure plays a contributing factor.