P
Philip Abraham
Researcher at Research Triangle Park
Publications - 83
Citations - 2589
Philip Abraham is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Tropane & Dopamine transporter. The author has an hindex of 30, co-authored 83 publications receiving 2542 citations. Previous affiliations of Philip Abraham include RTI International.
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Journal ArticleDOI
High-affinity binding of [125I]RTI-55 to dopamine and serotonin transporters in rat brain
John W. Boja,W M Mitchell,Amrat Patel,Theresa A. Kopajtic,Frank I. Carroll,Anita H. Lewin,Philip Abraham,Michael J. Kuhar +7 more
TL;DR: Results demonstrate that [125I]RTI‐55 may be a very useful ligand for the dopamine and serotonin transporters.
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Synthesis, ligand binding, QSAR, and CoMFA study of 3 beta-(p-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters.
F. Ivy Carroll,Yigong Gao,M. Abdur Rahman,Philip Abraham,Karol Parham,Anita H. Lewin,John W. Boja,Michael J. Kuhar +7 more
TL;DR: A series of 3 beta-(p-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters were synthesized and found to possess high affinity for the cocaine binding site in rat striatum.
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Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction.
F. Ivy Carroll,Bruce E. Blough,Philip Abraham,Andrew C. Mills,J. Ashley Holleman,Scott A. Wolckenhauer,Ann M. Decker,Antonio Landavazo,K. Timothy McElroy,Hernán A. Navarro,Michael B. Gatch,Michael J. Forster +11 more
TL;DR: Bupropion (2a) analogues were synthesized and tested for their ability to inhibit monoamine uptake and to antagonize the effects of human alpha3beta4*, alpha4 beta2, alpha4beta4, and alpha1* nAChRs.
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3-Aryl-2-(3'-substituted-1',2',4'-oxadiazol-5'-yl)tropane analogues of cocaine: affinities at the cocaine binding site at the dopamine, serotonin, and norepinephrine transporters.
Frank I. Carroll,Jeffrey J. Gray,Philip Abraham,Michael Kuzemko,Anita H. Lewin,JW Boja,Michael J. Kuhar +6 more
TL;DR: In general these bioisosteres showed potencies for the dopamine transporter similar to those of their parent esters.
Journal ArticleDOI
Synthesis, Ligand Binding, and QSAR (CoMFA and Classical) Study of 3.beta.-(3'-Substituted phenyl)-, 3.beta.-(4'-Substituted phenyl)-, and 3.beta.-(3',4'-Disubstituted phenyl)tropane-2.beta.-carboxylic Acid Methyl Esters
F. I. Carroll,S. W. Mascarella,Michael Kuzemko,Yigong Gao,Philip Abraham,Anita H. Lewin,JW Boja,Michael J. Kuhar +7 more
TL;DR: The CoM FA study provided new insight into the steric and electrostatic factors influencing binding to the DA transporter and provided additional support for the original finding that CoMFA is useful in predicting and designing new compounds for study.