Showing papers by "Philip L. McCarthy published in 1979"
TL;DR: The results indicate that the state of the microtubule system during the initial period of macrophage-MIF interaction determines the response to MIF.
11 citations
TL;DR: It has been known for some time that “activated” macrophages obtained from immune animals have altered morphology and metabolism, and that they show enhanced capacities to deal with a number of microorganisms.
Abstract: It has been known for some time that “activated” macrophages obtained from immune animals have altered morphology and metabolism, and that they show enhanced capacities to deal with a number of microorganisms (1,2). A number of these studies have shown that the lymphocyte is involved in these activation processes (3,4). Their action can be partially explained by the production of soluble mediators such as macrophage activating factor (MAF) which increases the capacity of macrophages to kill bacteria and tumor cells (5,6). This factor cannot be distinguished from migration inhibitory factor (MIF) (7,8,9).