P
Philip W. Jones
Researcher at Newbury College
Publications - 20
Citations - 1729
Philip W. Jones is an academic researcher from Newbury College. The author has contributed to research in topics: Virulence & Salmonella enterica. The author has an hindex of 17, co-authored 20 publications receiving 1695 citations.
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Journal ArticleDOI
An Inv/Mxi-Spa-like type III protein secretion system in Burkholderia pseudomallei modulates intracellular behaviour of the pathogen.
Mark P. Stevens,Michael W. Wood,Lowrie A. Taylor,Paul Monaghan,Pippa Hawes,Philip W. Jones,Timothy S. Wallis,Edouard E. Galyov +7 more
TL;DR: Findings indicate that the Bsa type III secretion system plays an essential role in modulating the intracellular behaviour of B. pseudomallei.
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Identification of SopE2, a Salmonella secreted protein which is highly homologous to SopE and involved in bacterial invasion of epithelial cells.
C. S. Bakshi,V. P. Singh,Michael W. Wood,Philip W. Jones,Timothy S. Wallis,Edouard E. Galyov +5 more
TL;DR: It is shown that SopE2 is an important invasion-associated effector in Salmonella pathogenicity and highly homologous to SopE, a protein encoded by a gene within a temperate bacteriophage and present in only some pathogenic strains.
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Characterization of intestinal invasion by Salmonella typhimurium and Salmonella dublin and effect of a mutation in the invH gene.
TL;DR: Salmonella dublin was found to be significantly less invasive in cultured cells than S. typhimurium, but this difference was not observed in bovine intestines, and the invH mutants exhibited a significant reduction in invasion in both cultured cells and bovines.
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Mutation of invH, but not stn, reduces Salmonella-induced enteritis in cattle
TL;DR: The invH mutation prevented the normal secretion of several proteins, including SipC, by S. typhimurium, indicating that the function of theinv-spa-encoded type III protein secretion system was disrupted, and other undefined serotype-specific virulence factors are also involved in Salmonella-induced enteritis.
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The Salmonella dublin virulence plasmid mediates systemic but not enteric phases of salmonellosis in cattle.
TL;DR: It is demonstrated that the virulence plasmid is not involved in either the enteric phase of infection or the systemic dissemination of Salmonella dublin but probably mediates the persistence of S. dublin at systemic sites.