https://cyberleninka.org/article/n/1331790.pdf

Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity

Salvia officinalis essential oil: Chemical analysis and evaluation of anti-enzymatic and antioxidant bioactivities

Oxidative stresses intensify the progression of diabetes-related behavioural changes and testicular injuries. Graviola (Annona muricata), a small tree of the Annonaceae family, has been investigated for its protective effects against diabetic complications, oxidative stress, and neuropathies. This study was planned to investigate the effects of graviola on behavioural alterations and testicular oxidative status of streptozotocin (STZ; 65 mg/kg)-induced diabetic rats. Forty adult male Wistar rats were equally allocated into four groups: control (received normal saline 8 ml/kg orally once daily), diabetic (received normal saline orally once daily), graviola (GR; received 100 mg/kg/day; orally once daily), and diabetic with graviola (Diabetic+GR; received 100 mg/kg/day; once daily). Behavioural functions were assessed using standard behavioural paradigms. Also, oxidative statuses of testis were evaluated. Results of behavioural observations showed that diabetes induced depression-like behaviours, reduction of exploratory and locomotor activities, decreased memory performance, and increased stress-linked behaviours. These variations in diabetic rats were happened due to oxidative stress. Interestingly, treatment of diabetic rats with graviola for four weeks alleviated all behavioural changes due to diabetes. Also, rats in graviola-treated groups had greater testicular testosterone and estradiol levels compared with diabetic rats due to significant rise in testicular acetyl-CoA acetyltransferase 2 expression. In the same context, graviola enhanced the antioxidant status of testicular tissues by significantly restoring the testicular glutathione and total superoxide dismutase that fell during diabetes. In addition, Graviola significantly decreased the expression of apoptotic (Bax) and inflammatory (interleukin-1β) testicular genes. In conclusion, these data propose that both the hypoglycemic and antioxidative potential of graviola are possible mechanisms that improve behavioural alterations and protect testis in diabetic animals. Concomitantly, further clinical studies in human are required to validate the current study.

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Graviola (Annona muricata) attenuates behavioural alterations and testicular oxidative stress induced by streptozotocin in diabetic rats.

The aim of the present study is to characterize chemical compositions and antioxidant, anticholinesterase and anti-tyrosinase activities of Ferula elaeochytris and Sideritis stricta essential oils....

https://journals.sagepub.com/doi/pdf/10.1177/1934578X1801300130

Essential Oil Composition, Antioxidant, Anticholinesterase and Anti-tyrosinase Activities of Two Turkish Plant Species: Ferula elaeochytris and Sideritis stricta:

The present study was undertaken to elucidate the comparative essential oil profile of various plant organs of Annona muricata L. (Soursop) using TLC and HPTLC methods. Toluene: Ethyl acetate (9.3:...

Chromatographic Fingerprint of Essential Oils in Plant Organs of Annona muricata L. (Annonaceae) using HPTLC

The chemical composition of the essential oils obtained by hydrodistillation from fresh leaves of four Annonaceae: Annona muricata, Annona squamosa, Monodora myristica and Xylopia aethiopica growing wild in Benin were analyzed by GC and GC/MS. Twenty four compounds were identified and quantified in the essential oil of Annona muricata with isocaryophyllene (20.2%); -caryophyllene (16.1%); cadinene (11.4%), elemene (8.9%); muurolene (6.9%) as major components. Twenty nine compounds were identified and quantified in the essential oil of Annona squamosa which contained isocaryophyllene (24.9%), camphene (10.2%), caryophyllene (2.6%), epi-cadinol + epimuurolol (9.2%) as prominent components. Essential oil of Monodora myristica screened contained twenty four components identified and quantified with phellandrene (65.5%), pinene (6.2%) as main compounds. Thirty three compounds were identified and quantified in the essential oils of Xylopia aethiopica, the major compounds being p-cymene (16.0%), sabinene (12.6%), terpinen-4-ol (11.3%), elemene (10.6%) and pinene (7.1%). The antiradical and anti-inflammatory activities of these oils were found to be low.

Philipe Sessou

Papers

Chemical composition, antiradical and anti-inflammatory activities of four annonaceae from benin