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Showing papers by "Philipp Hadwiger published in 2014"

Patent•
Novel lipids and compositions for intracellular delivery of biologically active compounds

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Rainer Constien, Anke Geick, Philipp Hadwiger, Torsten Haneke, Ludger Markus Ickenstein, Carla Alexandra Hernandez Prata, Andrea Schuster, Timo Weide 
12 Feb 2014
TL;DR: In this article, the authors provide novel amino-lipids, compositions comprising such amino -lipids and methods of producing them, as well as lipid nanoparticles comprising the novel amino lipids and a biologically active compound.
Abstract: The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.

121 citations

Patent•
Lna oligonucleotide carbohydrate conjugates

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Nanna Albæk1, Henrik Frydenlund Hansen1, Susanne Kammler1, Jacob Ravn1, Henrik Orum1, Mark Turner1, Monika Krampert1, Philipp Hadwiger1, Søren Ottosen1, Morten Lindow1 •
Hoffmann-La Roche1
30 Jan 2014
TL;DR: In this paper, the authors presented LNA therapeutics oligonucleotide carbohydrate conjugates with considerably enhanced potency, extended therapeutic index and reduced toxicity. But they did not describe the mechanism of the conjugation.
Abstract: The invention provides LNA therapeutics oligonucleotide carbohydrate conjugates with considerably enhanced potency, extended therapeutic index and reduced toxicity.

44 citations