Pierre Ernst

TL;DR: The finding of a halving in the rate of COPD hospitalisation associated with the use of etanercept corroborates the potential importance of TNF- α in the pathogenesis of COPd and supports the initiation of randomised controlled trials of this TNF - α antagonist among COPD patients at high risk of severe exacerbations.

TL;DR: The results of this study do not support a change in asthma phenotype with the onset of puberty, and the major determinant of bronchial hyperresponsiveness was skin sensitivity to mite allergen.

TL;DR: The results suggest that the frequency of asthma may be underestimated in HIV disease, and the frequent occurrence of BHR in HIV-infected men who smoke suggests this group may be especially susceptible to the adverse effects of cigarette smoke.

TL;DR: Evidence of adverse respiratory effects of ETS exposure in the home and office work environments in young adults during a study period of 8 years is provided, emphasizing the need for effective measures in the prevention of involuntary smoking during young adulthood.

TL;DR: Concerns are raised about the applicability of this systematic review to therapy as recommended by current guidelines and the subgroup analysis presented by Salpeter and colleagues according to the use of inhaled corticosteroids at baseline does not answer the relevant question of the safety of long-acting -agonists when used in conjunction with inhaled steroids.