Pieter Sipkema

TL;DR: The total amount of reflection in the arterial system of the dog is evaluated during control, high, and low peripheral resistance, and an occluded descending aorta.

TL;DR: An initial dysfunction of endothelial cells underlies metabolic and vascular alterations that contribute to the development of type 2 diabetes.

TL;DR: The cardiac muscle and the coronary vasculature are in close proximity to each other, and a two-way interaction, called cross-talk, exists, and here the authors focus on the mechanical aspects of cross- talk including the role of the extracellular matrix.

TL;DR: The hypothesis that left ventricular pressure is the sole determinant impeding coronary flow could not be confirmed, however, the data could be explained on basis of the time-varying elastance concept.

TL;DR: These findings support the hypothesis of altered microvascular reactivity to insulin in conditions of diminished PI3-kinase activity, a prominent feature of insulin resistance and demonstrate for the first time that vasoconstrictive effects of physiological concentrations of insulin during inhibition of NOS activity are mediated by endothelin.