Ping Li

TL;DR: The optimized nanoplatform, Rapa@ZIF-8, provides a proof of concept for intentionally interfering mTOR pathway and utilizing the switch of survival-to death-promoting autophagy for adjunct chemotherapy.

TL;DR: The results for the first time indicated that brucine could disrupt F-actin cytoskeleton and microtubule structure, thereby impairing hallmarks of aggressive tumors, like migration, invasion, and holding a possibility of suppressing vasculogenic mimicry.

TL;DR: Brucine inhibited triple negative breast cancer cells metastasis potentially through EMT reversion and MMP-2 and M MPs inhibition and decreased the protein and mRNA levels of mesenychmal markers such as vimentin and fibronectin.

TL;DR: In this article, a biomimetic liver lobule chip (LC) was developed for modeling non-alcoholic fatty liver disease (NAFLD) on a microfluidic chip, achieving self-organized liver microtissue that is similar to in vivo tissue.

TL;DR: In this article, a lifelike bionic liver lobule chip (LLC) was developed, on which the perfusable hepatic sinusoid networks were achieved using a microflow-guided angiogenesis methodology; additionally, during and after self-assembly, oxygen concentration was regulated to mimic physiologically dissolved levels supplied by actual hepatic arterioles and venules.