P
Ping Yin
Researcher at Northwestern University
Publications - 68
Citations - 3268
Ping Yin is an academic researcher from Northwestern University. The author has contributed to research in topics: Uterine leiomyoma & Leiomyoma. The author has an hindex of 30, co-authored 58 publications receiving 2808 citations. Previous affiliations of Ping Yin include Tohoku University & University of Yamanashi.
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Journal ArticleDOI
Progesterone resistance in endometriosis: Link to failure to metabolize estradiol
Serdar E. Bulun,You Hong Cheng,Ping Yin,Gonca Imir,Hiroki Utsunomiya,Erkut Attar,Joy Innes,J. Julie Kim +7 more
TL;DR: The cellular and molecular mechanisms underlying progesterone resistance and failure to metabolize E2 in endometriosis are reviewed.
Journal ArticleDOI
Promoter Methylation Regulates Estrogen Receptor 2 in Human Endometrium and Endometriosis
Qing Xue,Zhihong Lin,You Hong Cheng,Chiang Ching Huang,Erica E. Marsh,Ping Yin,Magdy P. Milad,Edmond Confino,Scott Reierstad,Joy Innes,Serdar E. Bulun,Serdar E. Bulun +11 more
TL;DR: Methylation of a CpG island at the ESR2 promoter region is a primary mechanism responsible for differential expression of ESR1 in endometriosis and endometrium and may be applied to a number of areas ranging from diagnosis to the treatment of endometRIosis.
Journal ArticleDOI
Estrogen Receptor-β, Estrogen Receptor-α, and Progesterone Resistance in Endometriosis
Serdar E. Bulun,You Hong Cheng,Mary Ellen Pavone,Qing Xue,Erkut Attar,Elena Trukhacheva,Hideki Tokunaga,Hiroki Utsunomiya,Ping Yin,Xia Luo,Zhihong Lin,Gonca Imir,Stephen F. Thung,Emily J. Su,J. Julie Kim +14 more
TL;DR: It is speculated that alterations in the relative levels of ERbeta and ERalpha in endometrial tissue dictate E2-regulated PR expression, such that a decreased ERalpha-tauomicron-ERbeta ratio may result in suppression of PR.
Journal ArticleDOI
Transcriptional Activation of Steroidogenic Factor-1 by Hypomethylation of the 5′ CpG Island in Endometriosis
Qing Xue,Zhihong Lin,Ping Yin,Magdy P. Milad,You Hong Cheng,Edmond Confino,Scott Reierstad,Serdar E. Bulun +7 more
TL;DR: This is the first demonstration of methylation-dependent regulation of SF-1 in any mammalian tissue and points to a new mechanism for targeting local estrogen biosynthesis in endometriosis.
Journal ArticleDOI
Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth
Masanori Ono,Ping Yin,Antonia Navarro,Molly B. Moravek,John S. Coon,Stacy A. Druschitz,Vanida Ann Serna,Wenan Qiang,David C. Brooks,Saurabh S. Malpani,Jiajia Ma,Cihangir Mutlu Ercan,Navdha Mittal,Diana Monsivais,Matthew T. Dyson,Alexander Yemelyanov,Tetsuo Maruyama,Debabrata Chakravarti,J. Julie Kim,Takeshi Kurita,Cara J. Gottardi,Serdar E. Bulun +21 more
TL;DR: It is demonstrated that wingless-type (WNT) acts as a paracrine signal from estrogen/progesterone receptor-rich mature cells to activate the canonical β-catenin pathway in leiomyoma stem cells, which enables mature myometrial or leoomyoma cells to send mitogenic signals to neighboring tissue stem cells in response to estrogen and progesterone.