Showing papers by "Piotr Bregestovski published in 1986"
TL;DR: The results suggest that the level of intracellular calcium regulates the effective number of K+ channels capable of being activated, and that the elevation of [Ca]i decreases the potassium conductance.
Abstract: Both voltage-activated potassium channels1–4 and the concentration of free intracellular calcium5,6 have been implicated in the activation of T lymphocytes. Using the patch-clamp technique7, we now show an unexpected relationship between the level of intracellular calcium [Ca]i in human lymphocytes and the amplitude of a voltage-dependent current: the elevation of [Ca]i decreases the potassium conductance. This is in contrast to other systems where [Ca]i activates K+ channels. Our results suggest that the level of intracellular calcium regulates the effective number of K+ channels capable of being activated.
100 citations