Synthesis and characterisation of tin(IV) and organotin(IV) derivatives 2-{[(2-hydroxyphenyl)imino]methyl}phenol

Diphenyltin(IV) complexes of the 2-quinolinecarboxaldehyde Schiff bases of S-methyl- and S-benzyldithiocarbazate (Hqaldsme and Hqaldsbz): X-ray crystal structures of Hqaldsme and two conformers of its diphenyltin(IV) complex

The present invention relates to the use of aminothiazole derivatives of Formula (I) of as inhibitors of PAI-1, and to novel classes of aminothiazole derivatives, their synthesis and their use as inhibitors of PAI-1. It has been discovered that compounds of Formula (I): or a solvate, hydrate or a pharmaceutically acceptable salt thereof, wherein Y, Ar?1, Ar2, R1, R2?, Z, m and n are described in the specification, inhibit plasminogen activator inhibitor-1 (PAI-1). These compounds can be used in the prophylaxis or for the treatment of thrombosis, angina pectoris, cerebral infarction, myocardial infarction, pulmonary infarction, intra-atrial thrombus in atrial fibrillation, deep venous thrombus, disseminated intravascular coagulation syndrome, diabetic complications, restenosis and stroke.

Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1

Unprecedented C-2 arylation of indole with diazonium salts: Syntheses of 2,3-disubstituted indoles and their antimicrobial activity.

The preparation and characterization of tin(IV) complexes of 2-quinolinecarboxaldehyde Schiff bases of S-methyl- and S-benzyldithiocarbazates and the X-ray crystal and molecular structures of the 2-quinolinecarboxaldehyde Schiff base of S-benzyldithiocarbazate (Hqaldsbz) and its tin(IV) complex [Sn(qaldsbz)I3]

Eleven fluorine containing condensed thiazoles have been synthesized and characterized by spectral (IR and NMR) studies. Fungicidal activity of some representative compounds has also been evaluated.

Synthesis of Some New Fluorine Containing Condensed Thiazoles and Their Fungicidal Activity

Syntheses of Some New Fluorine Containing Indole Derivatives and Their Antibacterial Activity

Sixteen fluorine containing 2-(N-arylamino)/2-methyl-4-aryl thiazoles have been synthesised and characterized by spectral (IR and NMR) studies. Some representative compounds have also been screened for their bactericidal activity.

Synthesis of Some New Fluorine Containing 2-(N-Arylamino)/2-methyl-4-aryl Thiazoles and Their Bactericidal Activity

Studies in potential organo-fluorine antibacterial agents. III. Synthesis of some new fluorine containing 2-(N-arylamino)/2-methyl-4-aryl thiazoles and their bactericidal activity.

Pramila Arya

Papers

Synthesis of Some New Fluorine Containing Condensed Thiazoles and Their Fungicidal Activity

Syntheses of Some New Fluorine Containing Indole Derivatives and Their Antibacterial Activity

Synthesis of Some New Fluorine Containing 2-(N-Arylamino)/2-methyl-4-aryl Thiazoles and Their Bactericidal Activity

Studies in potential organo-fluorine antibacterial agents. III. Synthesis of some new fluorine containing 2-(N-arylamino)/2-methyl-4-aryl thiazoles and their bactericidal activity.