This invention discloses a composition comprised of nanoparticles having a surface modifier adsorbed on the surface thereof and an anionic or cationic surfactant as a cloud point modifier associated therewith, which cloud point modifier is present in an amount sufficient to increase the cloud point of the surface modifier. A preferred surface modifier is tyloxapol. Preferred anionic surfactants are dioctylsulfonesuccinate, sodium dodecyl sulfate and sodium oleate. Preferred cationic surfactants are dodecyltrimethylammonium bromide and cetrimide tetradecyl ammonium bromide. This invention further discloses a method of making nanoparticles having a surface modifier adsorbed on the surface and an anionic or cationic surfactant as a cloud point modifier associated therewith, comprised of contacting said nanoparticles with the cloud point modifier for a time and under conditions sufficient to increase the cloud point of the surface modifier.

Use of ionic cloud point modifiers to prevent particle aggregation during sterilization.

A composition comprising nanoparticles having a surface modifier adsorbed on the surface thereof and a non-ionic cloud point modifier associated therewith, which cloud point modifier is present in an amount sufficient to increase the cloud point of the surface modifier and methods of making such nanoparticles is described. A preferred surface modifier is a poloxamine such as Tetronic 908, and preferred non-ionic cloud point modifiers include polyethylene glycol, propylene glycol, ethanol, hydroxypropylcyclodextrin and/or glycerol.

Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization.

The present invention is directed to methods for preventing crystal growth and particle aggregation in nanoparticulate compositions The methods comprise reducing a nanoparticulate composition to an optimal effective average particle size The resultant nanoparticulate compositions exhibit prolonged particle size stability and minimal crystal growth, even following exposure to elevated temperatures

Methods for preventing crystal growth and particle aggregation in nanoparticulate compositions

A method for identifying a compound that is a TGF-beta activator or production stimulator is provided.

Method for identifying an agent which increases TGF-beta levels

Described are an injectable formulation of nanoparticulate naproxen that produces minimal or no pain or burning sensation upon administration, and methods of making and using such a formulation. The injectable formulation comprises nanoparticulate naproxen having a povidone polymer adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 600 nm.

Injectable formulations of nanoparticulate naproxen

of EP0577215Dispersible particles consisting essentially of a crystalline anticancer agent having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 1000 nm. Anticancer compositions comprising the particles exhibit reduced toxicity and/or enhanced efficacy, and can be administered by intravenous injection.

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Papers

Process for obtaining surface modified anticancer nanoparticles