Polymeric Amorphous Solid Dispersions: A Review of Amorphization, Crystallization, Stabilization, Solid-State Characterization, and Aqueous Solubilization of Biopharmaceutical Classification System Class II Drugs

Amelioration of anticorrosion and hydrophobic properties of epoxy/PDMS composite coatings containing nano ZnO particles

Recent advances on organic coating system technologies for corrosion protection of offshore metallic structures

Polymer/Inorganic nanocomposite coatings with superior corrosion protection performance: A review

Hybrid polymeric based nanocomposite coating systems (NCs) were fabricated by solution intercalation method with the use of epoxy (E) and polydimethylsiloxane (PDMS) as the host hybrid polymeric matrix and different weight ratio of SiO2 nanoparticles, ranging from 2 wt. % to 8 wt. %, as the reinforcing agents. The effects of introducing PDMS as a modifier to epoxy resin, as well as, the influence of embedding SiO2 nanoparticles within the developed matrix were evaluated via utilizing X-ray diffraction (XRD), contact angle measurements (CA), field emission scanning electron microscope (FESEM), and electrochemical impedance spectroscopy (EIS). XRD and FESEM results revealed the good dispersion of the nanoparticles within the polymeric matrix and confirmed the efficiency of the solution intercalation method. CA findings confirmed the achievement of hydrophobic surface after modifying epoxy resin with PDMS with CA value at 96° for epoxy-PDMS coating system (ES 0). Also CA results indicated the ability of SiO2 nanoparticles to participate in developing more hydrophobic surface as CA value up to 132° was achieved with utilizing 6 wt% SiO2 loading ratio. The results obtained from EIS studies revealed that the coating system with 2 wt% had the best anticorrosion performance and have demonstrated an intact behavior over all the immersion period without any sign of coating damage or degradation.

Studies on SiO 2 -hybrid polymeric nanocomposite coatings with superior corrosion protection and hydrophobicity

Unique coating formulation for corrosion and microbial prevention of mild steel

Solid dispersion is molecular dispersion of drug in a polymer matrix which leads to improved solubility and hence better bioavailability. Solvent evaporation technique was employed to prepare films of different combinations of polymers, plasticizer, and a modal drug sulindac to narrow down on a few polymer-plasticizer-sulindac combinations. The sulindac-polymer-plasticizer combination that was stable with good film forming properties was processed by hot melt mixing, a technique close to hot melt extrusion, to predict its behavior in a hot melt extrusion process. Hot melt mixing is not a substitute to hot melt extrusion but is an aid in predicting the formation of molecularly dispersed form of a given set of drug-polymer-plasticizer combination in a hot melt extrusion process. The formulations were characterized by advanced techniques like optical microscopy, differential scanning calorimetry, hot stage microscopy, dynamic vapor sorption, and X-ray diffraction. Subsequently, the best drug-polymer-plasticizer combination obtained by hot melt mixing was subjected to hot melt extrusion process to validate the usefulness of hot melt mixing as a predictive tool in hot melt extrusion process.

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Formulation and Characterization of Solid Dispersion Prepared by Hot Melt Mixing: A Fast Screening Approach for Polymer Selection

Telmisartan (TEL), a BCS class II antihypertensive drug possesses poor aqueous solubility which results in poor bioavailability after oral administration. Solid dispersion approach has been widely and successfully used to improve the biopharmaceutical profiles of the poorly soluble drugs. Present study was an attempt to prepare and compare the solid dispersion (SD) of Telmisartan using a novel polymer soluplus® by employing spray drying and melt extrusion techniques. Results demonstrated an improvement in solubility of TEL by 44, 3.3, 11 and 99 times as compared to pure drug in water and buffers pH 1.2, 4.5 and 7.4 respectively, post preparation of solid dispersions. Further, similar improvement was observed in in vitro release studies highlighting the importance of formulating solid dispersion. DSC and PXRD study revealed the amorphous state of TEL in solid dispersion. The developed SD were found to be stable at 40°C/75% RH, 25°C/60% RH and 2-8°C in accordance to ICH guidelines. The pharmacokinetic study in rats revealed promising results which were correlated well with the in vitro dissolution and solubility study. Results indicated the usefulness of solid dispersions prepared using soluplus® by industrially viable techniques to improve not only the bioavailability of TEL but also their potential for commercialization.

Priya Dasan

Papers

Unique coating formulation for corrosion and microbial prevention of mild steel

Formulation and Characterization of Solid Dispersion Prepared by Hot Melt Mixing: A Fast Screening Approach for Polymer Selection

Formulation, Characterization and Pharmacokinetic Evaluation of TelmisartanSolid Dispersions