P
Purnima Narasimhan
Researcher at Stanford University
Publications - 39
Citations - 3902
Purnima Narasimhan is an academic researcher from Stanford University. The author has contributed to research in topics: Oxidative stress & Neuroprotection. The author has an hindex of 29, co-authored 38 publications receiving 3495 citations. Previous affiliations of Purnima Narasimhan include University of California, San Francisco.
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Journal ArticleDOI
Oxidative Stress in Ischemic Brain Damage: Mechanisms of Cell Death and Potential Molecular Targets for Neuroprotection
Hai Chen,Hideyuki Yoshioka,Gab Seok Kim,Joo Eun Jung,Nobuya Okami,Hiroyuki Sakata,Carolina M. Maier,Purnima Narasimhan,Christina E. Goeders,Pak H. Chan +9 more
TL;DR: It is proposed that superoxide dismutase and NOX activity in the brain is a major determinant for ischemic damage/repair and that these major anti- and pro-oxidant enzymes are potential endogenous molecular targets for stroke therapy.
Journal ArticleDOI
NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation
A. Brennan,Sang Won Suh,Seok Joon Won,Purnima Narasimhan,Tiina M. Kauppinen,Hokyou Lee,Ylva Edling,Pak H. Chan,Raymond A. Swanson +8 more
TL;DR: NADPH oxidase is identified as the primary source of NMDA-induced superoxide production and neuronal death, and is blocked by the NADPH oxid enzyme inhibitor apocynin and in neurons lacking the p47phox subunit, which is required for NADPH oxidation.
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Neuronal death/survival signaling pathways in cerebral ischemia.
Taku Sugawara,Miki Fujimura,Nobuo Noshita,Gyung Whan Kim,Atsushi Saito,Takeshi Hayashi,Purnima Narasimhan,Carolina M. Maier,Pak H. Chan +8 more
TL;DR: Cumulative evidence suggests that apoptosis plays a pivotal role in cell death in vitro after hypoxia and in in vivo ischemia models, and genetic manipulation of intrinsic antioxidants and factors in the signaling pathways has provided substantial understanding of the mechanisms involved.
Journal ArticleDOI
Reperfusion and Neurovascular Dysfunction in Stroke: from Basic Mechanisms to Potential Strategies for Neuroprotection
Joo Eun Jung,Gab Seok Kim,Hai Chen,Carolina M. Maier,Purnima Narasimhan,Yun Seon Song,Kuniyasu Niizuma,Masataka Katsu,Nobuya Okami,Hideyuki Yoshioka,Hiroyuki Sakata,Christina E. Goeders,Pak H. Chan +12 more
TL;DR: This study has developed a focal stroke model using mice deficient in mitochondrial manganese-superoxide dismutase (SOD2−/+) to investigate neurovascular endothelial damage that occurs during reperfusion and identified the signal transducer and activator of transcription 3 (STAT3) as a transcription factor of the mouse SOD2 gene.
Journal ArticleDOI
Oxidative stress and neuronal death/survival signaling in cerebral ischemia
Atsushi Saito,Carolina M. Maier,Purnima Narasimhan,Tatsuro Nishi,Yun Seon Song,Fengshan Yu,Jing Liu,Yong-Sun Lee,Chikako Nito,Hiroshi Kamada,Robert L. Dodd,Lily B. Hsieh,Benjamin Hassid,Esther Kim,Maricela González,Pak H. Chan +15 more
TL;DR: Genetic manipulation of intrinsic antioxidants and factors in the signaling pathways has provided substantial understanding of the mechanisms involved in cell death/survival signaling pathways and the role of oxygen radicals in ischemic cerebral injury.