Q
Qiang Li
Researcher at University of Alberta
Publications - 27
Citations - 1505
Qiang Li is an academic researcher from University of Alberta. The author has contributed to research in topics: Polycystin 2 & Ion channel. The author has an hindex of 20, co-authored 25 publications receiving 1389 citations.
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Journal ArticleDOI
Detecting protein-protein interactions by Far western blotting.
TL;DR: Far western blotting (WB) was derived from the standard WB method to detect protein–protein interactions in vitro and allows prey proteins to be endogenously expressed without purification.
Journal ArticleDOI
Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin
Yuliang Wu,Xiao-Qing Dai,Qiang Li,Carl X. Chen,Weiyi Mai,Zahir Hussain,Wentong Long,Nicolas Montalbetti,Guochun Li,Richard Glynne,Shaohua Wang,Horacio F. Cantiello,Guanqing Wu,Xing-Zhen Chen +13 more
TL;DR: Kinesin-2 is a linker between PC2 and FPC and mediates the regulation of PC2 channel function by FPC, which may be important for elucidating common molecular pathways for PKD of different genotypes.
Journal ArticleDOI
Alpha-actinin associates with polycystin-2 and regulates its channel activity
Qiang Li,Nicolas Montalbetti,Patrick Y. Shen,Xiao-Qing Dai,Chris I. Cheeseman,Edward Karpinski,Guanqing Wu,Horacio F. Cantiello,Xing-Zhen Chen +8 more
TL;DR: It is discovered that both intracellular N- and C-termini of PC2 associate with alpha-actinins, actin-binding and actin -bundling proteins important in cytoskeleton organization, cell adhesion, proliferation and migration.
Journal ArticleDOI
Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestine
Qiang Li,Andrei Manolescu,Mabel W.L. Ritzel,Sylvia Y.M. Yao,Melissa D. Slugoski,James D. Young,Xing-Zhen Chen,Chris I. Cheeseman +7 more
TL;DR: The unusual substrate specificity and close sequence identity with GLUT5 suggest that GLUT7 represents an intermediate between class II GLUTs and the class I member GLUT2, and comparison between these proteins may provide key information as to the structural determinants for the recognition of fructose as a substrate.
Journal ArticleDOI
Direct binding of α-actinin enhances TRPP3 channel activity
Qiang Li,Xiao-Qing Dai,Patrick Y. Shen,Yuliang Wu,Wentong Long,Carl X. Chen,Zahir Hussain,Shaohua Wang,Xing-Zhen Chen +8 more
TL;DR: Physical and functional interactions between TRPP3 and α‐actinin, an actin‐bundling protein known to regulate several types of ion channels, are investigated, finding that α‐actsinin not only attaches TR PP3 to the cytoskeleton but also up‐regulates TRPP 3 channel function.