Qiang Wang

TL;DR: A structure-based derivation of the AHNP represents a novel strategy for the design of receptor-specific tumor therapies for p185HER2/neu-expressing human cancers.

TL;DR: The high degree of asymptomatic shedding of live adenovirus in non-human primates and evidence for zoonotic transmissions warrants caution for primate handling and housing, and the presence of persistent and/or latent adnovirus infections in the gut should be considered in the design and interpretation of human and non- human primate studies with adanovirus vectors.

TL;DR: This first demonstration of the efficacy of intrathecal gene therapy in a large animal model of a LSD should pave the way for translation into the clinic.

TL;DR: Gene transfer to murine liver with vectors based on novel adeno-associated virus (AAV) serotypes is efficient, stable, and safe even in the setting of antigenic transgene products, and under some conditions primates may activate more robust T cell responses to transgenes than is observed in mice.

TL;DR: Study of two anti-p185 antibodies indicates that they share structural similarity in the variable region, especially the CDR3 region, which determines the antibody-antigen interaction, and suggests that 7.16.4 may be useful for the pathological diagnosis and therapy of human tumors.