The marine acid polysaccharide fucoidan has attracted attention from both the food and pharmaceutical industries due to its promising therapeutic effects. Fucoidan is a polysaccharide that mainly consists of L-fucose and sulphate groups. Its excellent biological function is attributed to its unique biological structure. Classical activities include antitumor, antioxidant, anticoagulant, antithrombotic, immunoregulatory, antiviral and anti-inflammatory effects. More recently, fucoidan has been shown to alleviate metabolic syndrome, protect the gastrointestinal tract, benefit angiogenesis and bone health. This review focuses on the progress in our understanding of the biological activities of fucoidan, highlighting its benefits for the treatment of human disease. We hope that this review can provide some theoretical basis and inspiration for the product development of fucoidan.

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Biological Activities of Fucoidan and the Factors Mediating Its Therapeutic Effects: A Review of Recent Studies

A review of natural polysaccharides for drug delivery applications: Special focus on cellulose, starch and glycogen.

Background Polysaccharides are a kind of biological macromolecular substance with multiple biological effects. Natural polysaccharides derived from plants and fungi are known as ideal raw food supplements for health food and pharmaceuticals due to their few side effects. Sulfated modification could significantly improve structure characteristics, promote bioactivities, and even add new bioactivities to polysaccharides. Thus, sulfated polysaccharides are increasingly causing more attention, as they have been proved to possess a variety of biological activities, including antioxidant, anticancer, and immunoregulatory, and anticoagulant activities. Furthermore, recent advances in synthesis, characterization and bioactivities of sulfated polysaccharides can promote its application in the food industry or pharmaceutics. Scope and approach This paper reviewed the main methods of sulfated modification, structural changes and the bioactivities of sulfated polysaccharide derivatives. We have comprehensively discussed biological activities of sulfated polysaccharides, emphatically the effects of sulfated group, composition, functional groups, as well as their replaced position on the bioactivities of sulfated polysaccharides, in order to reveal the potential mechanism of sulfation on bioactivities of polysaccharides. Key findings and conclusions This paper reviewed the recent research in the sulfated modification of polysaccharides and provided future directions for research in this area. There are many methods for sulfated modification, such as chlorosulfonic acid-pyridine method, concentrated sulfuric acid method, and sulfur trioxide-pyridine method, which could improve anti-coagulant, anti-oxidative, immunoregulation, anti-tumor, and anti-virus activities of polysaccharides. Sulfated modification could change bioactivities of polysaccharides due to their effects on structure characteristics. DS, monosaccharide compositions, replaced position of sulfated groups were considered to contribute to their bioactivities promotion. Further studies are required to explore the application of sulfated polysaccharides in pharmaceutical and food industries.

Sulfated modification of polysaccharides: Synthesis, characterization and bioactivities

https://biblio.ugent.be/publication/8702100/file/8703895.pdf

Modification approaches of plant-based proteins to improve their techno-functionality and use in food products

Pectin is a polymer with a core of alternating α-1,4-linked d-galacturonic acid and α-1,2-l-rhamnose units, as well as a variety of neutral sugars such as arabinose, galactose, and lesser amounts of other sugars. Currently, native pectins have been compared to modified ones due to the development of natural medicines and health products. In this review, the results of a study of the bioactivity of pectic polysaccharides, including its various pharmacological applications, such as its immunoregulatory, anti-inflammatory, hypoglycemic, antibacterial, antioxidant and antitumor activities, have been summarized. The potential of pectins to contribute to the enhancement of drug delivery systems has been observed.

Biological Activity and Pharmacological Application of Pectic Polysaccharides: A Review.

Biological activities and pharmaceutical applications of polysaccharide from natural resources: A review

Review of the relationships among polysaccharides, gut microbiota, and human health.

Gel properties and interactions of Mesona blumes polysaccharide-soy protein isolates mixed gel: The effect of salt addition.

Two water-soluble polysaccharides from mung bean skin: Physicochemical characterization, antioxidant and antibacterial activities

Effect of high-pressure microfluidization treatment on the physicochemical properties and antioxidant activities of polysaccharide from Mesona chinensis Benth.

Qianqian Song

Papers

Biological activities and pharmaceutical applications of polysaccharide from natural resources: A review

Review of the relationships among polysaccharides, gut microbiota, and human health.

Gel properties and interactions of Mesona blumes polysaccharide-soy protein isolates mixed gel: The effect of salt addition.

Two water-soluble polysaccharides from mung bean skin: Physicochemical characterization, antioxidant and antibacterial activities

Effect of high-pressure microfluidization treatment on the physicochemical properties and antioxidant activities of polysaccharide from Mesona chinensis Benth.