Comparison of Electrospun and Extruded Soluplus®-based Solid Dosage Forms of Improved Dissolution

Combined additive manufacturing approaches in tissue engineering.

Bone defect and osteoporosis are common in clinic which are seriously harmful for public health. Bionic bone tissue engineering scaffolds are very important for bone tissue repair and reconstruction. In this study, different bionic bone tissue engineering scaffolds were constructed by computer-aided design and fabricated by selected laser melting. Novel porous structures were designed by using parameterization modeling. The accurate models with key characteristics such as porosity and the mechanical property of scaffolds were studied. Compared with the designed model, the error of the selective laser melting (SLM) printed scaffold porosity was less than 2.73%. The mechanical properties of the prepared scaffold can be calculated by finite element analysis of 3D models, and the mechanical properties of the 3D printed samples were consistent with the model design. Through the design, manufacture, characterization and evaluation of the scaffold porous structures, the parametric modeling of porous titanium bone tissue engineering scaffold with good mechanical and biological properties was realized. Optimized design and precisely manufactured implants are very important for bone tissue repair and reconstruction.

Bionic design and 3D printing of porous titanium alloy scaffolds for bone tissue repair

Purpose – This paper aims to review the advances in additive manufactured (AM) scaffolds for bone tissue engineering (TE). A discussion on the state of the art and future trends of bone TE scaffolds have been done in terms of design, material and different AM technologies. Design/methodology/approach – Different structural features and materials used for bone TE scaffolds are evaluated along with the discussion on the potential and limitations of different AM scaffolds. The latest research to improve the biocompatibility of the AM scaffolds is also discussed. Findings – The discussion gives a clear understanding on the recent research trend in bone TE AM scaffolds. Originality/value – The information available here would be useful for the researchers working on AM scaffolds to get a quick overview on the recent research trends and/or future direction to work on AM bone TE scaffolds.

State of the art and future direction of additive manufactured scaffolds-based bone tissue engineering

Three-dimensional (3D) printing, as one of the most popular recent additive manufacturing processes, has shown strong potential for the fabrication of biostructures in the field of tissue engineering, most notably for bones, orthopedic tissues, and associated organs. Desirable biological, structural, and mechanical properties can be achieved for 3D-printed constructs with a proper selection of biomaterials and compatible bioprinting methods, possibly even while combining additive and conventional manufacturing (AM and CM) procedures. However, challenges remain in the need for improved printing resolution (especially at the nanometer level), speed, and biomaterial compatibilities, and a broader range of suitable 3D-printed materials. This review provides an overview of recent advances in the development of 3D bioprinting techniques, particularly new hybrid 3D bioprinting technologies for combining the strengths of both AM and CM, along with a comprehensive set of material selection principles, promising medical applications, and limitations and future prospects.

https://www.mdpi.com/2073-4360/12/8/1717/pdf

3D Bioprinting in Tissue Engineering for Medical Applications: The Classic and the Hybrid.

A novel method of designing and preparing bone tissue engineering scaffolds with controllable porous structure of both macro channels and micro pores was proposed. The CAD software UG NX3.0 was used to design the macro channels’ shape, size and distribution. By integrating rapid prototyping and traditional porogen technique, the macro channels and micro pores were formed respectively. The size, shape and quantity of micro pores were controlled by porogen particulates. The sintered β-TCP porous scaffolds possessed connective macro channels of approximately 500 μm and micro pores of 200–400 μm. The porosity and connectivity of micro pores became higher with the increase of porogen ratio, while the mechanical properties weakened. The average porosity and compressive strength of β-TCP scaffolds prepared with porogen ratio of 60wt% were 78.12% and 0.2983 MPa, respectively. The cells’ adhesion ratio of scaffolds was 67.43%. The ALP activity, OCN content and cells micro morphology indicated that cells grew and proliferated well on the scaffolds.

Design and preparation of bone tissue engineering scaffolds with porous controllable structure

The invention relates to a stereolithography-based process for manufacturing the porous structure of a bionic scaffold. The process comprises the following steps: scanning natural bones by Micro-CT to acquire the micro-structural model of the natural bones; further acquiring the negative-type model thereof through the Boolean operation; then, acquiring the negative-type model on a stereolithography basis; and finally pouring bioceramic slurry followed by high-temperature calcinations to obtain the controllable porous structure of the bionic scaffold. The porous structure of the bionic scaffold prepared by the method is the same as the real structure of bones; moreover, the method is even more favorable for the adhesion, creeping and osteogenesis substitution of cells.

Stereolithography-based process for manufacturing porous structure of bionic scaffold

Electrospinning is an advanced manufacturing technology combined with machinery, automatic control and computing technology, it is popular used in numbers of fields and has appealed the attention of a great many scholars in and aboard, and its controllable ability has become the fuscous point. In order to make seize of the fiber diameter and realize the collection aligned, this paper designed a new device basing on the analysis of the influence elements during the electrospinning experiment in the direction of process control to achieve effectively organization on these parameters. What’s more, the writer showed not only the mechanical structure, but also the corresponding system design, focusing on the plan of coordination multi-axis motion with movement control CARDS. After all, this device is able to complete the effective coordination of spray distance and the target velocity, and improves the manage ability of the whole device operation.

A New Spurts Controllable Electrospinning Collecting Device Designed Basing on Advanced Motion Control

Porous β-tricalcium phosphate (β-TCP) ceramic scaffolds with axially oriented macropore and random micropore were produced by selective laser sintering (SLS) process. Microstructure parameters including pore size, pore size distribution and interconnectivity were quantified by microcomputed tomography. Compressive mechanical properties were tested. The porosity of sintered scaffolds was over 60%. The range of average compressive modulus and ultimate strength was 24.38∼30.64MPa and 1.64∼2.35MPa, respectively. Dog bone marrow stromal cells (BMSCs) were seeded in the prepared scaffolds. Cell proliferation and osteogenic differentiation on the scaffolds were evaluated with the alkaline phosphatase (ALP) activity and osteocalcin (OCN) content.

Effect of microstructure on the mechanical properties and biology performance of bone tissue scaffolds using selective laser sintering

Now some people suffer from the bone defects for various reasons, and how to solve this problem has become a hot topic internationally in the field of tissue engineering. By the analysis of all kinds of the bone defects, an all-purpose approach using bionic bone scaffold to repair the bone defects is proposed in this paper to help the doctors to diagnose the state of the bone defect illness with the real models manufactured by the rapid prototyping technology. Meanwhile, a clinic application is given to prove the feasibility of this approach.

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Qingxi Hu

Papers

Design and preparation of bone tissue engineering scaffolds with porous controllable structure

Stereolithography-based process for manufacturing porous structure of bionic scaffold

A New Spurts Controllable Electrospinning Collecting Device Designed Basing on Advanced Motion Control

Effect of microstructure on the mechanical properties and biology performance of bone tissue scaffolds using selective laser sintering

Modeling Technology and Application of Repairing Bone Defects Based on Rapid Prototyping