Q
Qiyue Hu
Researcher at Pfizer
Publications - 21
Citations - 861
Qiyue Hu is an academic researcher from Pfizer. The author has contributed to research in topics: Integrase & Integrase inhibitor. The author has an hindex of 15, co-authored 21 publications receiving 791 citations.
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Journal ArticleDOI
Aldehyde oxidase: an enzyme of emerging importance in drug discovery.
TL;DR: Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340.
Journal ArticleDOI
Systematic Structure Modifications of Imidazo[1,2-a]pyrimidine to Reduce Metabolism Mediated by Aldehyde Oxidase (AO)
Angelica Linton,Ping Kang,Martha A. Ornelas,Kephart Susan Elizabeth,Qiyue Hu,Pairish Mason Alan,Ying Jiang,Chuangxing Guo +7 more
TL;DR: A investigation revealed the most probable site of AO oxidation and the observation that altering the heterocycle or blocking the reactive site are two of the more effective strategies for reducing AO metabolism may be useful for other drug discovery programs.
Journal ArticleDOI
Discovery of the highly potent PI3K/mTOR dual inhibitor PF-04691502 through structure based drug design
Cheng Hengmiao,Shubha Bagrodia,Simon Bailey,Martin Paul Edwards,Jacqui Elizabeth Hoffman,Qiyue Hu,Robert Steven Kania,Daniel R. Knighton,Matthew A. Marx,Sacha Ninkovic,Shaoxian Sun,Eric Zhang +11 more
TL;DR: Lead optimization through integration of structure based drug design (SBDD) and physical properties-based optimization (PPBO) led to the discovery of 2-amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin
Journal ArticleDOI
Azaindole hydroxamic acids are potent HIV-1 integrase inhibitors.
Plewe Michael Bruno,Scott L. Butler,Klaus Ruprecht Dress,Qiyue Hu,Ted William Johnson,Jon E. Kuehler,Atsuo Kuki,Hieu Lam,Wen Liu,Nowlin Dawn Marie,Qinghai Peng,Sadayappan V. Rahavendran,Steven P. Tanis,Tran Khanh Tuan,Hai Wang,Yang Anle,Zhang Junhu +16 more
TL;DR: Several 4-fluorobenzyl substituted azaindole hydroxamic acids showed potent antiviral activities in cell-based assays and offered a structurally simple scaffold for the development of novel HIV-1 IN inhibitors.
Journal ArticleDOI
Pfizer Global Virtual Library (PGVL): a chemistry design tool powered by experimentally validated parallel synthesis information.
Qiyue Hu,Zhengwei Peng,Sutton Scott Channing,Jim Na,Jaroslav Kostrowicki,Bo Yang,Thomas Thacher,Xianjun Kong,Sarathy Mattaparti,Joe Zhongxiang Zhou,Javier Gonzalez,Michele Ramirez-Weinhouse,Atsuo Kuki +12 more
TL;DR: The chemistry information within PGVL has been used to extract synthesis and design information using an intuitive desktop Graphic User Interface, PGVL Hub.