Qun Lu

TL;DR: Two components of an amorphous solid mixture containing citric acid and indomethacin with limited solid state miscibility can be solublized as an amomorphous solid phase by the addition of moderate levels of PVP.

TL;DR: It was shown that citric acid is a fairly fragile liquid expected to exhibit non-Arrhenius dynamic behavior and that the presence of residual water at a level of 8.6% causes a decrease in fragility.

TL;DR: It is concluded that colyophilization of acidicsubstances with sucrose, even in the absence of residual water, can produce reducing sugars capable of further reaction with other formulation ingredients susceptible to reaction with reducing sugars.