Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

Glucose control and vascular complications in veterans with type 2 diabetes

Trease and Evans' pharmacognosy

Diabetes mellitus is one of the major health problems in the world, the incidence and associated mortality are increasing. Inadequate regulation of the blood sugar imposes serious consequences for health. Conventional antidiabetic drugs are effective, however, also with unavoidable side effects. On the other hand, medicinal plants may act as an alternative source of antidiabetic agents. Examples of medicinal plants with antidiabetic potential are described, with focuses on preclinical and clinical studies. The beneficial potential of each plant matrix is given by the combined and concerted action of their profile of biologically active compounds.

https://www.mdpi.com/2218-273X/9/10/551/pdf

Antidiabetic Potential of Medicinal Plants and Their Active Components.

Pentacyclic triterpenoids including the oleanane, ursane and lupane groups are widely distributed in many medicinal plants,such as Glycyrrhiza species, Gymnema species, Centella asiatica, Camellia sinensis, Crataegus species and Olea europaea, which arecommonly used in traditional medicine for the treatment of diabetes and diabetic complications. A large number of bioactive pentacyclictriterpenoids, such as oleanolic acid, glycyrrhizin, glycyrrhetinic acid, ursolic acid, betulin, betulinic acid and lupeol have shown multiplebiological activities with apparent effects on glucose absorption, glucose uptake, insulin secretion, diabetic vascular dysfunction, retinopathyand nephropathy. The versatility of the pentacyclic triterpenes provides a promising approach for diabetes management.

The Pentacyclic Triterpenoids in Herbal Medicines and Their Pharmacological Activities in Diabetes and Diabetic Complications

Objective To assess the antioxidant and in vitro anti-inflammatory activities of the alcoholic extract of Mimusops elengi L (M. elengi) leaves. Methods In vitro antioxidant activity was evaluated for peroxynitrite, superoxide and hypochlorous acid scavenging activity. Total phenolic content also determined. Inhibition of protein denaturation and HRBC (Human Red Blood Cell) membrane stabilization method was evaluated for anti-inflammatory activity. Results The leave extract of M. elengi exhibited dose dependent free radical scavenging property in peroxynitrite, superoxide and hypochlorous acid models and the IC50 value were found to be (205.53 ± 2.30), (60.5±2.3), (202.4±5.3) μg/mL respectively. Total phenolic content was found to be 97.3 μg/mg of extract. The maximum membrane stabilization of M. elengi L was found to be (73.85±0.80)% at a dose of 1 000 μg/0.5 mL and that of protein denaturation was found to be 86.23% at a dose of 250 μg/mL with regards to standards in the anti-inflammatory activity. Conclusion From the result it can conclude that M. elengi extract show good antioxidant and in vitro anti -inflammatory activities.

Antioxidant and in vitro anti-inflammatory activities of Mimusops elengi leaves

Evaluation of antitumor activity and in vivo antioxidant status of Anthocephalus cadamba on Ehrlich ascites carcinoma treated mice.

Context: Terminalia arjuna Roxb. (Combretaceae), commonly known as Arjuna, is a large tree grown throughout the Indian peninsula and used traditionally for several medicinal purposes.Objective: To evaluate antihyperglycemic and antioxidant role of methanol extract of T. arjuna leaf (META) in Wistar rats.Materials and methods: Hyperglycemia was induced in rats by single intraperitoneal injection of streptozotocin (STZ, 65 mg/kg body weight). Three days after STZ induction, the hyperglycemic rats were treated with META orally at the dose of 100 and 200 mg/kg body weight daily for 15 days. Glibenclamide (0.5 mg/kg, orally) was used as reference drug. The fasting blood glucose levels were measured on every fifth day during the 15-day treatment. Serum biochemical parameters such as serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), cholesterol, and total protein were estimated. Antioxidant properties were assessed by estimating hepatic li...

https://www.tandfonline.com/doi/pdf/10.3109/13880209.2010.516755

Antihyperglycemic activity and antioxidant role of Terminalia arjuna leaf in streptozotocin-induced diabetic rats.

Evaluation of antihyperglycemic activity of Cocos nucifera Linn. on streptozotocin induced type 2 diabetic rats.

Introduction
Clerodendron infortunatum Linn. (Verbenaceae), commonly known as Bhant in Hindi, is a small shrub occurring throughout the plains of India, which is traditionally used for several medicinal purposes. The aim of the present study was to evaluate the preclinical antihyperglycemic activity of the methanol extract of the leaves of C. infortunatum (MECI) in Wistar rats.

/pdf/preclinical-evaluation-of-antihyperglycemic-activity-of-3i3l5y8uzk.pdf

R.B. Suresh Kumar

Papers

Antioxidant and in vitro anti-inflammatory activities of Mimusops elengi leaves

Evaluation of antitumor activity and in vivo antioxidant status of Anthocephalus cadamba on Ehrlich ascites carcinoma treated mice.

Antihyperglycemic activity and antioxidant role of Terminalia arjuna leaf in streptozotocin-induced diabetic rats.

Evaluation of antihyperglycemic activity of Cocos nucifera Linn. on streptozotocin induced type 2 diabetic rats.

Preclinical evaluation of antihyperglycemic activity of Clerodendron infortunatum leaf against streptozotocin-induced diabetic rats